2024-03-29T10:57:04Zhttp://digital.lib.washington.edu/dspace-oai/requestoai:digital.lib.washington.edu:1773/157282016-02-14T11:37:38Zcom_1773_11634com_1773_3774col_1773_11649
2010-04-21T15:50:02Z
urn:hdl:1773/15728
Role of metabolically active hormones in the insulin resistance associated with short-term glucocorticoid treatment
Patel, Jeetesh V.
Cummings, David E.
Girod, John P.
Mascarenhas, Alwin Y.
Hughes, Elizabeth A.
Gupta, Manjula
Lip, Gregory Y. H.
Reddy, Sethu
Brotman, Daniel J.
Background: The mechanisms by which glucocorticoid therapy promotes obesity and insulin resistance are incompletely characterized. Modulations of the metabolically active hormones, tumour necrosis factor alpha (TNF alpha), ghrelin, leptin and adiponectin are all implicated in the development of these cardiovascular risk factors. Little is known about the effects of short-term
glucocorticoid treatment on levels of these hormones. Research methods and procedures: Using a blinded, placebo-controlled approach, we randomised 25 healthy men (mean (SD) age: 24.2 (5.4) years) to 5 days of treatment with either
placebo or oral dexamethasone 3 mg twice daily. Fasting plasma TNFa, ghrelin, leptin and adiponectin were measured before and after treatment.
Results: Mean changes in all hormones were no different between treatment arms, despite dexamethasone-related increases in body weight, blood pressure, HDL cholesterol and insulin. Changes in calculated indices of insulin sensitivity (HOMA-S, insulin sensitivity index) were strongly related to dexamethasone treatment (p less than 0.001).
Discussion: Our data do not support a role for TNF alpha, ghrelin, leptin or adiponectin in the insulin resistance associated with short-term glucocorticoid treatment.
2010-04-21T15:50:02Z
2010-04-21T15:50:02Z
2006
Article
Patel J, Cummings D, Girod J, et al. Role of metabolically active hormones in the insulin resistance associated with short-term glucocorticoid treatment. Journal of Negative Results in BioMedicine. 2006;5(1):14.
10.1186/1477-5751-5-14
http://www.jnrbm.com/content/5/1/14
http://hdl.handle.net/1773/15728
en_US