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Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression
(Endocrine Society, 2005-05)
In previous studies of testicular biopsy tissue from healthy men,
intratesticular testosterone (ITT) has been shown to be much higher than
serum testosterone (T), suggesting that high ITT is needed relative to
serum T for normal spermatogenesis in men. However, the quantitative
relationship between ...
Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene
(American Society of Hematology, 1996-07-01)
Fanconi anemia (FA) is an autosomal recessive chromosome instability
syndrome characterized by progressive bone marrow (BM) failure, skeletal
defects, and increased susceptibility to malignancy. FA cells are
hypersensitive to DNA cross-linking agents, oxygen and have cell cycle
abnormalities. To ...
Impairment of Spermatogonial Development and Spermiation after Testosterone-Induced Gonadotropin Suppression in Adult Monkeys (Macaca fascicularis)
(The Endocrine Society, 2001-04)
Human male hormonal contraceptive regimens do not consistently induce
azoospermia, and the basis of this variable response is unclear. This
study used nine adult macaque monkeys (Macaca fascicularis) given
testosterone (T) implants for 20 weeks to study changes in germ cell
populations in relation ...
Immature spermatids are not prevalent in semen from men who are receiving androgen-based contraceptive regimens
(Elsevier, 1998-01)
OBJECTIVE: To determine whether immature spermatids increase in semen in
response to hormonal contraceptive treatments. Such a finding would
support the existence of a defect in spermiogenesis, which in turn may
explain the reported variability in sperm output. DESIGN: Semen smears
were obtained ...
Male hormonal contraception: suppression of spermatogenesis by injectable testosterone undecanoate alone or with levonorgestrel implants in chinese men
(American Society of Andrology, 2004-09)
Monthly injections of testosterone undecanoate (TU) act as a male
contraceptive by reversibly suppressing spermatogenesis to azoospermia or
severe oligoazoospermia in 95% of Chinese men. In 5% of Chinese men,
however, monthly TU administered alone fails to suppress spermatogenesis
into contraceptive ...
Age-related analysis of inhibin A, inhibin B, and activin a relative to the intercycle monotropic follicle-stimulating hormone rise in normal ovulatory women
(Endocrine Society, 2004-06)
Previous studies have reported that the monotropic rise in FSH in older
women is associated with decreased inhibin B and/or A levels and increased
levels of activin A. Whereas most investigators have found decreased
follicular-phase inhibin B, the roles of inhibin A and activin A as
modulators of ...
Leptin is a metabolic signal to the reproductive system
(Endocrine Society, 1996-07)
Leptin, a newly-discovered hormonal product of the obese (ob) gene, is
expressed by adipocytes and thought to play a role in the regulation of
food intake and metabolism. We tested the hypothesis that leptin signals
metabolic information to the reproductive system by examining its effects
on the ...
The gene encoding PRBP, the mouse homolog of human TRBP, maps to distal chromosome 15
(Springer-Verlag, 1998-05)
No abstract or description.
Quantitative (stereological) study of the normal spermatogenesis in the adult monkey (Macaca fascicularis)
(American Society of Andrology, 1997-11)
Germ cell and Sertoli cell numbers were estimated in six normal adult
monkeys (Macaca fascicularis) using a contemporary unbiased and efficient
stereological method--the optical disector. The data was used to assess
the efficiency of spermatogenesis from type B spermatogonia to elongated
spermatids. ...
Suppression of spermatogenesis in man induced by Nal-Glu gonadotropin releasing hormone antagonist and testosterone enanthate (TE) is maintained by TE alone
(Endocrine Society, 1998-10)
GnRH antagonists plus testosterone (T) suppress LH and FSH levels and
inhibit spermatogenesis to azoospermia or severe oligozoospermia.
High-dose T treatment alone has been shown to be an effective male
contraceptive (contraceptive efficacy rate of 1.4 per 100 person yr).
Combined GnRH antagonist ...