Prehn, R. On the nature of cancer and why anticancer vaccines don't work

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Prehn, R. On the nature of cancer and why anticancer vaccines don't work

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dc.contributor.author Prehn, Richmond T. en_US
dc.date.accessioned 2010-05-06T20:03:41Z
dc.date.available 2010-05-06T20:03:41Z
dc.date.issued 2005 en_US
dc.identifier.citation On the nature of cancer and why anticancer vaccines don't work. Cancer Cell International. 2005;5(1):25. en_US
dc.identifier.other 10.1186/1475-2867-5-25 en_US
dc.identifier.uri http://www.cancerci.com/content/5/1/25 en_US
dc.identifier.uri http://hdl.handle.net/1773/15823
dc.description.abstract In this essay I suggest that the major difficulty in producing effective anti-cancer vaccines lies in the fact that most cancers have little immunogenicity because of a basic paucity of tumor-specific antigenicity. The lack of antigenicity, despite extensive genomic instability, could be explained if most tumor mutations occur in silenced genes. A further problem is that an immune reaction against tumor antigens, especially in moderate or low amount, may be stimulatory rather than inhibitory to tumor growth. en_US
dc.description.sponsorship en_US
dc.language.iso en_US en_US
dc.title Prehn, R. On the nature of cancer and why anticancer vaccines don't work en_US
dc.type Article en_US


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