A surrogate method for comparison analysis of salivary concentrations of Xylitol-containing products

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A surrogate method for comparison analysis of salivary concentrations of Xylitol-containing products

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dc.contributor.author Riedy, Christine A. en_US
dc.contributor.author Milgrom, Peter en_US
dc.contributor.author Ly, Kiet A. en_US
dc.contributor.author Rothen, Marilynn en_US
dc.contributor.author Mueller, Gregory en_US
dc.contributor.author Hagstrom, Mary K. en_US
dc.contributor.author Tolentino, Ernie en_US
dc.contributor.author Zhou, Lingmei en_US
dc.contributor.author Roberts, Marilyn C. en_US
dc.date.accessioned 2010-05-06T20:04:57Z
dc.date.available 2010-05-06T20:04:57Z
dc.date.issued 2008 en_US
dc.identifier.citation Riedy C, Milgrom P, Ly K, et al. A surrogate method for comparison analysis of salivary concentrations of Xylitol-containing products. BMC Oral Health. 2008;8(1):5. en_US
dc.identifier.other 10.1186/1472-6831-8-5 en_US
dc.identifier.uri http://www.biomedcentral.com/1472-6831/8/5 en_US
dc.identifier.uri http://hdl.handle.net/1773/15834
dc.description.abstract Background: Xylitol chewing gum has been shown to reduce Streptococcus mutans levels and decay. Two studies examined the presence and time course of salivary xylitol concentrations delivered via xylitol-containing pellet gum and compared them to other xylitol-containing products. Methods: A within-subjects design was used for both studies. Study 1, adults (N = 15) received three xylitol-containing products (pellet gum (2.6 g), gummy bears (2.6 g), and commercially available stick gum (Koolerz, 3.0 g)); Study 2, a second group of adults (N = 15) received three xylitol-containing products (pellet gum, gummy bears, and a 33% xylitol syrup (2.67 g). For both studies subjects consumed one xylitol product per visit with a 7-day washout between each product. A standardized protocol was followed for each product visit. Product order was randomly determined at the initial visit. Saliva samples (0.5 mL to 1.0 mL) were collected at baseline and up to 10 time points (~16 min in length) after product consumption initiated. Concentration of xylitol in saliva samples was analyzed using high-performance liquid chromatography. Area under the curve (AUC) for determining the average xylitol concentration in saliva over the total sampling period was calculated for each product. Results: In both studies all three xylitol products (Study 1: pellet gum, gummy bears, and stick gum; Study 2: pellet gum, gummy bears, and syrup) had similar time curves with two xylitol concentration peaks during the sampling period. Study 1 had its highest mean peaks at the 4 min sampling point while Study 2 had its highest mean peaks between 13 to 16 minutes. Salivary xylitol levels returned to baseline at about 18 minutes for all forms tested. Additionally, for both studies the total AUC for the xylitol products were similar compared to the pellet gum (Study 1: pellet gum - 51.3 [micro]g.min/mL, gummy bears - 59.6 [micro]g.min/mL, and stick gum - 46.4 [micro]g.min/mL; Study 2: pellet gum - 63.0 [micro]g.min/mL, gummy bears - 55.9 [micro]g.min/mL, and syrup - 59.0 [micro]g.min/mL). Conclusion: The comparison method demonstrated high reliability and validity. In both studies other xylitol-containing products had time curves and mean xylitol concentration peaks similar to xylitol pellet gum suggesting this test may be a surrogate for longer studies comparing various products. en_US
dc.description.sponsorship NIDCR-NIH U54 DE14254; Head Start, HRSA 90YD0188/03; and MCHB, HRSA R40MC03622-03. en_US
dc.language.iso en_US en_US
dc.title A surrogate method for comparison analysis of salivary concentrations of Xylitol-containing products en_US
dc.type Article en_US


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