Heterogeneity of psychophysiological stress responses in fibromyalgia syndrome patients

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Heterogeneity of psychophysiological stress responses in fibromyalgia syndrome patients

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dc.contributor.author Thieme, Kati en_US
dc.contributor.author Turk, Dennis C. en_US
dc.date.accessioned 2010-05-06T20:08:34Z
dc.date.available 2010-05-06T20:08:34Z
dc.date.issued 2005 en_US
dc.identifier.citation Thieme K, Turk D. Heterogeneity of psychophysiological stress responses in fibromyalgia syndrome patients. Arthritis Research and Therapy. 2006;8(1):R9. en_US
dc.identifier.other 10.1186/ar1863 en_US
dc.identifier.uri http://arthritis-research.com/content/8/1/R9 en_US
dc.identifier.uri http://hdl.handle.net/1773/15867
dc.description.abstract Dysregulated psychophysiological responses have been observed in patients with fibromyalgia syndrome (FMS), although the results are inconsistent. Surface electromyographic (EMG), systolic and diastolic blood pressure, heart rate (HR), and skin conductance levels (SCLs) were continuously recorded at baseline, and during a series of stress and relaxation tasks in 90 FMS patients and 30 age and sex matched healthy controls (HCs). The patient sample demonstrated lower baseline EMG levels compared to the HCs on all tasks. In contrast, the patients displayed elevated HR and SCL (sympathetic vasomotor and sudomotor indices, respectively) during both stress tasks. A cluster analysis identified four psychophysiological response patterns: 63.3% of HCs showed increased muscle tension and stable cardiovascular responses; 34.8% of FMS patients showed a pattern of increased sympathetic vasomotor reactivity with stable sudomotor and reduced muscular response; 12.2% of FMS patients showed a pattern of increased sympathetic sudomotor reactivity connected with increased sympathetic vasomotor response and reduced muscular response; and, in contrast, 46.7% of FMS patients showed a pattern of parasympathetic vasomotor reactivity and reduced sudomotor as well as muscular response. The identification of low baseline muscle tension in FMS is discrepant with other chronic pain syndromes and suggests that unique psychophysiological features may be associated with FMS. The different psychophysiological response patterns within the patient sample support the heterogeneity of FMS. en_US
dc.description.sponsorship Grants from the Deutsche Forschungsgemeinschaft to KT (Th 899-1/2 and 899-2/2), and grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR44724 and AR 47298) to DCT. en_US
dc.language.iso en_US en_US
dc.title Heterogeneity of psychophysiological stress responses in fibromyalgia syndrome patients en_US
dc.type Article en_US


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