Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat

ResearchWorks/Manakin Repository

Search ResearchWorks


Advanced Search

Browse

My Account

Statistics

Related Information

Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat

Show simple item record

dc.contributor.author Van Dijk, Gertjan
dc.contributor.author Seely, Randy J.
dc.contributor.author Thiele, Todd E.
dc.contributor.author Friedman, Mark I.
dc.contributor.author Ji, Hong
dc.contributor.author Wilkinson, Charles W.
dc.contributor.author Burn, Paul
dc.contributor.author Campfield, Arthur
dc.contributor.author Tenenbauim, Renata
dc.contributor.author Raskin, Denis G.
dc.contributor.author Woods, Stephen C.
dc.date.accessioned 2011-11-23T21:39:28Z
dc.date.available 2011-11-23T21:39:28Z
dc.date.issued 1999
dc.identifier.uri http://hdl.handle.net/1773/19327
dc.description.abstract Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1425–R1433, 1999.—To investigate whether brain leptin involves neuropeptidergic pathways influencing ingestion, metabolism, and gastrointestinal functioning, leptin (3.5 μg) was infused daily into the third cerebral ventricular of rats for 3 days. To distinguish between direct leptin effects and those secondary to leptin-induced anorexia, we studied vehicle-infused rats with food available ad libitum and those that were pair-fed to leptin-treated animals. Although body weight was comparably reduced (28%) and plasma glycerol was comparably increased (142 and 17%, respectively) in leptin-treated and pair-fed animals relative to controls, increases in plasma fatty acids and ketones were only detected (132 and 234%, respectively) in pair-fed rats. Resting energy expenditure (215%) and gastrointestinal fill (250%) were reduced by pair-feeding relative to the ad libitum group, but they were not reduced by leptin treatment. Relative to controls, leptin increased hypothalamic mRNA for corticotropin-releasing hormone (CRH; 61%) and for proopiomelanocortin (POMC; 31%) but did not reduce mRNA for neuropeptide Y. These results suggest that CNS leptin prevents metabolic/gastrointestinal responses to caloric restriction by activating hypothalamic CRH- and POMC-containing pathways and raise the possibility that these peripheral responses to CNS leptin administration contribute to leptin’s anorexigenic action. en_US
dc.language.iso en en_US
dc.publisher American Psychological Society en_US
dc.subject OB Protein en_US
dc.subject sympathetic nervous system en_US
dc.subject corticotropinreleasing en_US
dc.subject hormone en_US
dc.subject proopiomelanocortin; en_US
dc.subject food intake en_US
dc.title Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat en_US
dc.type Article en_US


Files in this item

Files Size Format View
Metabolic, gast ... nistration in the rat..pdf 323.2Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record