Germline bottlenecks and the evolutionary maintenance of mitochondrial genomes

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Germline bottlenecks and the evolutionary maintenance of mitochondrial genomes

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dc.contributor.author Bergstrom, Carl T. en_US
dc.contributor.author Pritchard, Jonathan K. en_US
dc.date.accessioned 2004-11-04T05:02:49Z en_US
dc.date.accessioned 2007-06-13T19:58:22Z
dc.date.available 2004-11-04T05:02:49Z en_US
dc.date.available 2007-06-13T19:58:22Z
dc.date.issued 1998-08 en_US
dc.identifier.citation Bergstrom, C. T. and J. K. Pritchard. 1998. Genetics 149:2135-2146 en_US
dc.identifier.issn 0016-6731 en_US
dc.identifier.uri http://hdl.handle.net/1773/2009 en_US
dc.description.abstract Several features of the biology of mitochondria suggest that mitochondria might be susceptible to Muller’s ratchet and other forms of evolutionary degradation: Mitochondria have predominantly uniparental inheritance, appear to be nonrecombining, and have high mutation rates producing significant deleterious variation. We demonstrate that the persistence of mitochondria may be explained by recent data that point to a severe “bottleneck” in the number of mitochondria passing through the germline in humans and other mammals. We present a population-genetic model in which deleterious mutations arise within individual mitochondria, while selection operates on assemblages of mitochondria at the level of their eukaryotic hosts. We show that a bottleneck increases the efficacy of selection against deleterious mutations by increasing the variance in fitness among eukaryotic hosts. We investigate both the equilibrium distribution of deleterious variation in large populations and the dynamics of Muller’s ratchet in small populations. We find that in the absence of the ratchet, a bottleneck leads to improved mitochondrial performance and that, over a longer time scale, a bottleneck acts to slow the progression of the ratchet. en_US
dc.format.extent 194445 bytes en_US
dc.format.mimetype application/pdf en_US
dc.language.iso en_US en_US
dc.publisher Genetics en_US
dc.title Germline bottlenecks and the evolutionary maintenance of mitochondrial genomes en_US
dc.type Article en_US


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