Clinical outcomes following pre- and post-operative vitamin D supplementation in Roux-en-Y Gastric Bypass patients

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Clinical outcomes following pre- and post-operative vitamin D supplementation in Roux-en-Y Gastric Bypass patients

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dc.contributor.advisor Chan, Lingtak-Neander en_US
dc.contributor.author Neilson, Charlotte en_US
dc.date.accessioned 2012-08-10T20:32:57Z
dc.date.available 2012-08-10T20:32:57Z
dc.date.issued 2012-08-10
dc.date.submitted 2012 en_US
dc.identifier.other Neilson_washington_0250O_10089.pdf en_US
dc.identifier.uri http://hdl.handle.net/1773/20275
dc.description Thesis (Master's)--University of Washington, 2012 en_US
dc.description.abstract <bold>Background:</bold> Bariatric surgery is associated with risks for micronutrient deficiencies. For example, hypovitaminosis D (25(OH)D ≤30ng/mL) has been reported in obese individuals and patients who received Roux-en-Y gastric bypass (RYGB). Investigations on incidence of hypovitaminosis D in patients undergoing bariatric surgery in the Pacific Northwest are limited. The primary aim of this study was to identify the incidence of hypovitaminosis D in patients prior to RYGB. The relationship between 25(OH)D status and patient characteristics (age, gender, ethnicity, BMI, comorbidities) was analyzed. The secondary aim was to analyze longitudinal change in 25(OH)D concentration 1 year post-operatively. <bold>Methods:</bold> A cohort study involving adult patients undergoing RYGB was conducted. Longitudinal change in serum vitamin D concentrations and clinical parameters were collected. <bold>Results:</bold> Baseline data were analyzed in 134 patients. Hypovitaminosis D was identified in 90 patients (incidence of 67%), and was significantly affected by seasonal change and the number of comorbidities. Longitudinal data were available in 60 patients. Vitamin D sufficiency was achieved in 62.5% of those patients with baseline vitamin D insufficiency. A dose-response relationship of vitamin D intake was observed, with the most significant increase in 25(OH)D associated with daily vitamin D intakes ≥2000IU. <bold>Conclusions:</bold> A significant number of patients have hypovitaminosis D at baseline. Daily vitamin D intake meeting at least 2000IU is associated with greater improvement in serum vitamin D concentration. en_US
dc.format.mimetype application/pdf en_US
dc.language.iso en_US en_US
dc.subject Bariatric Surgery; Nutritional Deficiency; Obesity; Roux-en-Y; Vitamin D en_US
dc.subject.other Nutrition en_US
dc.subject.other Nutritional sciences en_US
dc.title Clinical outcomes following pre- and post-operative vitamin D supplementation in Roux-en-Y Gastric Bypass patients en_US
dc.type Thesis en_US
dc.embargo.terms No embargo en_US


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