Association of Age at Menarche and Menstrual Characteristics with Adult Onset Asthma among Reproductive Age Women

ResearchWorks/Manakin Repository

Search ResearchWorks


Advanced Search

Browse

My Account

Statistics

Related Information

Association of Age at Menarche and Menstrual Characteristics with Adult Onset Asthma among Reproductive Age Women

Show full item record

Title: Association of Age at Menarche and Menstrual Characteristics with Adult Onset Asthma among Reproductive Age Women
Author: FIDA, NEWAY GESSESSE
Abstract: University of Washington Abstract Association of Age at Menarche and Menstrual Characteristics with Adult Onset Asthma among Reproductive Age Women Neway Gessesse Fida Chair of the Supervisory Committee: Assistant Professor Daniel A. Enquobahrie Department of Epidemiology Objective: To evaluate associations of early menarche and menstrual characteristics with adult onset asthma among reproductive age women. Methods: Study participants were selected from among women enrolled in a pregnancy cohort study. Information on age at menarche, menstrual characteristics, and history of asthma was collected using interviewer-administered questionnaires. Adult onset asthma was defined as asthma first diagnosed after onset of menarche. Women who had no information on asthma and menstrual history were excluded. In addition, women who were diagnosed with asthma before menarche were excluded. A total of 3,461 women comprised the analytic population. Logistic regression was used to estimate adjusted relative risk (aRR) and 95% confidence intervals (95% CI) relating age at menarche and menstrual characteristics with adult onset asthma. Results: Mean age at menarche was 12.8 years (standard deviation=1.46). Among study participants, 7.5% were diagnosed with asthma after the onset of menarche. After controlling for potential confounders (age, race, body mass index, and socio-economic status), women who had early menarche (<12 years old) had 60% higher risk of being diagnosed with adult onset asthma as compared with women who did not have early menarche (¡Ý 12 years old) (aRR: 1.59, 95% CI: 1.19 ¨C 2.13). Menstrual irregularities or abnormal (short or long) cycle length were not associated with risk of adult onset asthma. In addition, no significant interaction was observed between age at menarche or menstrual characteristics with body mass index or physical activity (in adolescence) in relation to adult onset asthma. Conclusion: Early menarche is associated with a higher risk of developing adult onset asthma among reproductive age women. Mechanisms for this association are potential areas of future research.
Description: Thesis (Master's)--University of Washington, 2012
URI: http://hdl.handle.net/1773/20530
Author requested restriction: Restrict to UW for 1 year -- then make Open Access

Files in this item

Files Size Format View
FIDA_washington_0250O_10345.pdf 521.5Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record