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Decreased ACTH and Cortisol Responses to Stress in Healthy Adults Reporting Significant Childhood Maltreatment
(Biol. Psychiatry, 2007-11-15)
Background—Preclinical research findings suggest that exposure to stress and concomitant
hypothalamus-pituitary-adrenal (HPA) axis activation during early development can have permanent
and potentially deleterious effects. A history of early-life abuse or neglect appears to increase risk
for mood and anxiety disorders. ...
Acute Modulation of Aged Human Memory by Pharmacological Manipulation of Glucocorticoids
(The Endocrine Society, 2002)
In a previous longitudinal study of basal cortisol levels and
cognitive function in humans, we showed that elderly humans
with 4- to 7-yr cumulative exposure to high levels of cortisol
present memory impairments, compared with elderly humans
with moderate cortisol levels over years. Here, we measured
whether memory ...
Human Glucocorticoid Feedback Inhibition Is Reduced in Older Individuals: Evening Study
(The Journal of Clinical Endocrinology & Metabolism, 2001)
We have previously shown that when tested in the morning, older
men and women, pretreated with metyrapone to block endogenous
cortisol synthesis, exhibit delayed suppression of plasma ACTH in
response to cortisol infusion. To confirm this finding and to determine
whether aging-related changes in feedback responsiveness ...
Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin , and plasma insulin to youthful levels
(Endocrinology, 1999)
No abstract or description.
Adrenocortical responsiveness to infusions of physiological doses of ACTH is not altered in posttraumatic stress disorder
(Frontiers in Behavioral Neuroscience, 2009-10-30)
Early studies of posttraumatic stress disorder (PTSD) reported that abnormal function of the
hypothalamic–pituitary–adrenocortical (HPA) system was associated with the disorder. However,
subsequent studies attempting to identify a specifi c aspect of HPA dysfunction that characterizes
PTSD have been marked by considerable ...
The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia
(Am J Physiol Endocrinol Metab., 2008-05)
Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for patients with comorbid
diabetes and depression. Clinical case studies in diabetic patients, however, suggest that SSRI therapy
may exacerbate hypoglycemia. We hypothesized that SSRIs might increase the risk of hypoglycemia
by impairing hormonal ...
Aerobic Exercise Improves Cognition for Older Adults with Glucose Intolerance, A Risk Factor for Alzheimer’s Disease
(JOURNAL OF ALZHEIMER'S DISEASE, 2010)
Impaired glucose regulation is a defining characteristic of type 2 diabetes mellitus (T2DM)
pathology and has been linked to increased risk of cognitive impairment and dementia. Although
the benefits of aerobic exercise for physical health are well-documented, exercise effects on
cognition have not been examined for older ...
Recurrent hypoglycemia alters hypothalamic expression of the regulatory proteins FosB and synaptophysin
(American Journal of Physiology, 2008-08-27)
A limiting factor to the clinical management of diabetes is iatrogenic hypoglycemia. With multiple hypoglycemic
episodes, the collective neuroendocrine response that restores euglycemia is impaired. In our animal model of
recurrent hypoglycemia (RH), neuroendocrine deficits are accompanied by a decrease in medial ...
Diesel Exhaust Inhalation Elicits Acute Vasoconstriction in Vivo
(Environmental Health Perspectives, 2008-07-07)
BACKGROUND: Traffic-related air pollution is consistently associated with cardiovascular morbidity
and mortality. Recent human and animal studies suggest that exposure to air pollutants affects vascular
function. Diesel exhaust (DE) is a major source of traffic-related air pollution.
OBJECTIVES: Our goal was to study the ...
Acute THPVP inactivation decreases the glucagon and sympathoadrenal responses to recurrent hypoglycemia
(Brain Res, 2008-02-15)
The posterior paraventricular nucleus of the thalamus (THPVP) has been identified as a forebrain
region that modulates the central nervous system (CNS) response to recurrent experiences of
stressors. The THPVP is activated in response to a single (SH) or recurrent (RH) experience of the
metabolic stress of hypoglycemia. ...