Browsing Center for Research in Reproduction and Contraception by Title
Now showing items 1-20 of 220
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Abnormal patterns of pulsatile luteinizing hormone in women with luteal phase deficiency
(Elsevier, 1984-05)Luteal phase deficiency is usually a problem of inadequate progesterone production associated with inadequate ovarian follicular development. The hypothesis that luteal phase deficiency results from an abnormal ... -
Absence of germline infection in male mice following intraventricular injection of adenovirus
(Elsevier, 2001-12)The possibility of inadvertent exposure of gonadal tissue to gene therapy vectors has raised safety concerns about germline infection. We show here that the receptor for coxsackie B viruses and adenoviruses ... -
Activation of the sympathetic nervous system by galanin-like peptide--a possible link between leptin and metabolism
(Endocrine Society, 2003-11)The effects of leptin upon body weight (BW) cannot be explained by its anorectic actions alone. Part of the metabolic changes elicited by leptin includes sympathetic nervous system activation leading to ... -
Activation-dependent regulation of galanin gene expression in gonadotropin-releasing hormone neurons in the female rat [see comments]
(Endocrine Society, 1994-05)In rats, galanin is colocalized in GnRH neurons, and galanin mRNA in GnRH neurons is increased coincidentally with the preovulatory gonadotropin surge. Whether the induction of galanin mRNA in GnRH neurons ... -
Acyline: the first study in humans of a potent, new gonadotropin-releasing hormone antagonist
(Endocrine Society, 2002-07)Acyline is a novel GnRH antagonist found in animal studies to be a potent suppressor of circulating gonadotropin and testosterone (T) levels. We conducted the first study of acyline administration to humans. ... -
Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study
(Endocrine Society, 2002-02)We used longitudinal data from the Massachusetts Male Aging Study, a large population-based random-sample cohort of men aged 40-70 yr at baseline, to establish normative age trends for serum level of T and ... -
Age-related analysis of inhibin A, inhibin B, and activin a relative to the intercycle monotropic follicle-stimulating hormone rise in normal ovulatory women
(Endocrine Society, 2004-06)Previous studies have reported that the monotropic rise in FSH in older women is associated with decreased inhibin B and/or A levels and increased levels of activin A. Whereas most investigators have found ... -
Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids
(Company Of Biologists Limited, 2004-01)Androgen receptor function is required for male embryonic sexual differentiation, pubertal development and the regulation of spermatogenesis in mammals. During spermatogenesis, this requirement is ... -
Androgen receptor gene expression in the rat central nervous system: evidence for two mRNA transcripts
(Elsevier, 1991-04)Androgen receptor (AR) gene expression in the central nervous system (CNS) and peripheral tissues of male rats was examined using cDNA probes to measure AR mRNA by RNA (Northern) blot analysis and by in situ hybridization. ... -
Annual patterns of luteinizing hormone, follicle stimulating hormone, testosterone and inhibin in normal men
(Oxford University Press, 1996-02)Reproductive functions in most animals demonstrate seasonal fluctuations that allow young to be born at a time of the year favourable for their survival. Whether there is a seasonal change in the human ... -
The anterior pituitary response to a gonadotropin-releasing hormone challenge test in normal older reproductive-age women
(Elsevier, 1996-03)OBJECTIVE: To assess the pituitary responsiveness to GnRH stimulation of premenopausal women relative to age. DESIGN: Older and younger reproductive-age women underwent the GnRH stimulation test in the early ... -
The association of D-group chromosomal translocations and defective spermatogenesis
(Elsevier, 1976-02)D-group chromosome translocations have been associated in isolated cases with infertility in males. In this study, we demonstrated the effect of a translocated D-group chromosome on spermatogenesis as it had ... -
An automated technique for the radiographic determination of bone age
(Blackwell Publishing, 1982)We have developed an automated procedure for determining bone-age in the monkey, Macaca fascicularis. The status of epiphysial junctions and sesamoids were determined from radiographs. Epiphyses were scored ... -
Bone mineral content of amenorrheic and eumenorrheic athletes
(Massachusetts Medical Society, 1984-08-02)This study was designed to determine whether the hypoestrogenic status of 14 amenorrheic athletes was associated with a decrease in regional bone mass relative to that of 14 of their eumenorrheic peers. The ... -
Case 15-2004: cancer therapy and sperm banking
(Massachusetts Medical Society, 2004-07-29) -
The central role of Sertoli cells in spermatogenesis
(Elsevier, 1998-08)Sertoli cells are the somatic cells of the testis that are essential for testis formation and spermatogenesis. Sertoli cells facilitate the progression of germ cells to spermatozoa via direct contact and by ... -
Chronic human chorionic gonadotropin administration in normal men: evidence that follicle-stimulating hormone is necessary for the maintenance of quantitatively normal spermatogenesis in man
(Endocrine Society, 1986-06)The role of FSH in the maintenance of spermatogenesis in man is poorly understood. To determine whether normal serum levels of FSH are necessary for the maintenance of quantitatively normal spermatogenesis, ... -
Circadian variation in testosterone, sex hormone-binding globulin, and calculated non-sex hormone-binding globulin bound testosterone in healthy young and elderly men
(American Society of Andrology, 1989-09)The circadian pattern in levels of serum total testosterone (T) in men becomes blunted with normal aging. However, because T not bound to sex hormone-binding globulin (non-SHBG-T) is felt to be a better ... -
A clinical trial of injectable testosterone undecanoate as a potential male contraceptive in normal Chinese men
(Endocrine Society, 1999-10)This is a pilot dose-finding study of spermatogenic suppression using testosterone undecanoate (TU) injections alone in normal Chinese men. Thirty-two healthy men were recruited. Volunteers underwent ... -
Cloning and characterization of the mouse interleukin enhancer binding factor 3 (Ilf3) homolog in a screen for RNA binding proteins
(Springer-Verlag, 1999-05)In a screen for RNA-binding proteins expressed during murine spermatogenesis, we have identified a cDNA that encodes a protein of 911 amino acids that contains two copies of the double-stranded RNA-binding ...