A role for kisspeptins in the regulation of gonadotropin secretion in the mouse

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A role for kisspeptins in the regulation of gonadotropin secretion in the mouse

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dc.contributor.author Clifton, Donald K. en_US
dc.contributor.author Steiner, Robert A. en_US
dc.contributor.author Smith, Jeremy T. en_US
dc.contributor.author Gottsch, Michelle L. en_US
dc.contributor.author Crowley, W. F. en_US
dc.contributor.author Acohido, B. V. en_US
dc.contributor.author Cunningham, Matthew J. en_US
dc.contributor.author Popa, Simina M. en_US
dc.contributor.author Seminara, S. en_US
dc.date.accessioned 2008-10-17T20:40:30Z
dc.date.available 2008-10-17T20:40:30Z
dc.date.issued 2004-09 en_US
dc.identifier.citation Endocrinology. 2004 Sep;145(9):4073-7. Epub 2004 Jun 24 en_US
dc.identifier.uri http://hdl.handle.net/1773/4310
dc.description.abstract Kisspeptins are products of the KiSS-1 gene, which bind to a G protein-coupled receptor known as GPR54. Mutations or targeted disruptions in the GPR54 gene cause hypogonadotropic hypogonadism in humans and mice, suggesting that kisspeptin signaling may be important for the regulation of gonadotropin secretion. To examine the effects of kisspeptin-54 (metastin) and kisspeptin-10 (the biologically active C-terminal decapeptide) on gonadotropin secretion in the mouse, we administered the kisspeptins directly into the lateral cerebral ventricle of the brain and demonstrated that both peptides stimulate LH secretion. Further characterization of kisspeptin-54 demonstrated that it stimulated both LH and FSH secretion, at doses as low as 1 fmol; moreover, this effect was shown to be blocked by pretreatment with acyline, a potent GnRH antagonist. To learn more about the functional anatomy of kisspeptins, we mapped the distribution of KiSS-1 mRNA in the hypothalamus. We observed that KiSS-1 mRNA is expressed in areas of the hypothalamus implicated in the neuroendocrine regulation of gonadotropin secretion, including the anteroventral periventricular nucleus, the periventricular nucleus, and the arcuate nucleus. We conclude that kisspeptin-GPR54 signaling may be part of the hypothalamic circuitry that governs the hypothalamic secretion of GnRH. en_US
dc.language.iso en_US en_US
dc.publisher Endocrine Society en_US
dc.subject mice en_US
dc.subject kisspeptins en_US
dc.subject gonadotropin en_US
dc.subject secretion en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Hypothalamus, drug effects, metabolism, secretion en_US
dc.subject.mesh Proteins, genetics, metabolism, pharmacology en_US
dc.subject.mesh Mice en_US
dc.subject.mesh Luteinizing Hormone, metabolism, secretion en_US
dc.subject.mesh Male en_US
dc.subject.mesh Mice, Inbred C57BL en_US
dc.subject.mesh Gonadorelin, metabolism en_US
dc.subject.mesh RNA, Messenger, analysis en_US
dc.subject.mesh Receptors, Neuropeptide, metabolism en_US
dc.subject.mesh Injections, Intraventricular en_US
dc.subject.mesh Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.title A role for kisspeptins in the regulation of gonadotropin secretion in the mouse en_US
dc.type Article en_US


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