Differential patterns of Fos induction in the hypothalamus of the rat following central injections of galanin-like peptide and galanin

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Differential patterns of Fos induction in the hypothalamus of the rat following central injections of galanin-like peptide and galanin

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dc.contributor.author Clifton, Donald K. en_US
dc.contributor.author Baumgartner, James W. en_US
dc.contributor.author Steiner, Robert A. en_US
dc.contributor.author Fraley, Gregory S. en_US
dc.contributor.author Shimada, Issei en_US
dc.date.accessioned 2008-10-17T20:40:32Z
dc.date.available 2008-10-17T20:40:32Z
dc.date.issued 2003-04 en_US
dc.identifier.citation Endocrinology. 2003 Apr;144(4):1143-6 en_US
dc.identifier.uri http://hdl.handle.net/1773/4312
dc.description.abstract Galanin and its newly discovered relative galanin-like peptide (GALP) are neuropeptides that are implicated in the neuroendocrine regulation of body weight and reproduction. GALP has been shown to bind in vitro to galanin receptor subtypes 1 and 2, but whether it has its own specific receptor(s) is unknown. We reasoned that if GALP acts through a receptor that is distinct from galanin receptors, then GALP should activate central pathways that are different from those activated by galanin. The purpose of this study was to determine whether galanin and GALP produce different patterns of neuronal activation within the hypothalamus. Quantitative analysis of Fos immunoreactivity showed that galanin induced a significantly greater number of Fos-positive nuclei in the paraventricular nucleus compared with GALP (P < 0.001); however, compared with galanin, GALP induced significantly more Fos-positive cells in the horizontal limb of the diagonal band of Broca, caudal preoptic area, arcuate nucleus, and median eminence (P < 0.05). These observations suggest that GALP and galanin act through different receptor-mediated pathways to exert their effects on the regulation of body weight and reproduction and identify target cells for GALP's specific actions in the hypothalamus, including the preoptic area, paraventricular and arcuate nuclei, and the median eminence. en_US
dc.language.iso en_US en_US
dc.publisher Endocrine Society en_US
dc.subject Fos induction en_US
dc.subject hypothalamus en_US
dc.subject galanin-like peptide en_US
dc.subject rat en_US
dc.subject galanin en_US
dc.subject.mesh Injections, Intraventricular en_US
dc.subject.mesh Hypothalamus, drug effects, metabolism en_US
dc.subject.mesh Nerve Tissue Proteins, pharmacology en_US
dc.subject.mesh Preoptic Area, drug effects, metabolism en_US
dc.subject.mesh Male en_US
dc.subject.mesh Cerebrospinal Fluid en_US
dc.subject.mesh Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh Proto-Oncogene Proteins c-fos, biosynthesis en_US
dc.subject.mesh Rats en_US
dc.subject.mesh Paraventricular Hypothalamic Nucleus, drug effects, metabolism en_US
dc.subject.mesh Galanin, pharmacology en_US
dc.subject.mesh Galanin-Like Peptide en_US
dc.subject.mesh Feeding Behavior, drug effects en_US
dc.subject.mesh Rats, Sprague-Dawley en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Arcuate Nucleus, drug effects, metabolism en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.title Differential patterns of Fos induction in the hypothalamus of the rat following central injections of galanin-like peptide and galanin en_US
dc.type Article en_US


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