Relationship between testosterone supplementation and insulin-like growth factor-I levels and cognition in healthy older men

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Relationship between testosterone supplementation and insulin-like growth factor-I levels and cognition in healthy older men

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Title: Relationship between testosterone supplementation and insulin-like growth factor-I levels and cognition in healthy older men
Author: Cherrier, M. M.; Mohan, S.; Matsumoto, Alvin M.; Peskind, E.; Latendresse, S.; Bremner, William J.; Raskind, M.; Craft, S.; Plymate, Stephen R.; Haley, A. P.; Asthana, S.
Abstract: BACKGROUND: Our laboratory has previously reported that testosterone (T) administration to older men significantly improves cognitive function. This study examined potential changes in insulin-like growth factor (IGF) IGF-I, IGF-II and IGF-related binding proteins in response to T administration in older men and their relationship to cognitive functioning. METHODS: Twenty-five healthy community dwelling volunteers, ranging in age from 50-80 years were randomized to receive weekly intra-muscular (i.m.) injections of either 100 mg T enanthate or placebo (saline) for 6 weeks. Serum hormone levels and cognitive functioning was assessed at baseline and twice during treatment. RESULTS: Significant positive associations between IGF-I and IGF-II and spatial memory, spatial reasoning, and verbal fluency were observed after 6 weeks of T administration. Increased serum T levels from treatment were positively associated with improvement in spatial reasoning performance, whereas estradiol was associated with a decline in divided attention performance. Serum IGF-I, IGF-II and IGFBPs did not change in response to T treatment. CONCLUSIONS: Our results suggest that T, estradiol and IGF-I may have independent and selective effects on cognitive functioning. Positive associations between T levels and cognition are consistent with an effect of androgen treatment, whereas positive associations between IGF-I levels and cognition are reflective of a relationship between endogenous IGF-I levels and cognition.
URI: http://hdl.handle.net/1773/4330

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