Abnormal patterns of pulsatile luteinizing hormone in women with luteal phase deficiency

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Abnormal patterns of pulsatile luteinizing hormone in women with luteal phase deficiency

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dc.contributor.author Bremner, William J. en_US
dc.contributor.author Clifton, Donald K. en_US
dc.contributor.author Soules, Michael R. en_US
dc.contributor.author Steiner, Robert A. en_US
dc.date.accessioned 2008-10-17T20:41:34Z
dc.date.available 2008-10-17T20:41:34Z
dc.date.issued 1984-05 en_US
dc.identifier.citation Obstet Gynecol. 1984 May;63(5):626-9 en_US
dc.identifier.uri http://hdl.handle.net/1773/4363
dc.description.abstract Luteal phase deficiency is usually a problem of inadequate progesterone production associated with inadequate ovarian follicular development. The hypothesis that luteal phase deficiency results from an abnormal secretion pattern of luteinizing hormone (LH) was tested in these women. To this end, the early follicular LH secretion pattern in four women with luteal phase deficiency was characterized and compared with patterns in normal women. Blood samples were obtained through indwelling catheters every ten minutes for eight hours (10 AM to 6 PM), and plasma levels of LH and FSH were measured. Luteinizing hormone and FSH secretion profiles were analyzed for pulse frequency, amplitude, and mean plasma level. A significantly greater LH pulse frequency in women with luteal phase deficiency was observed when compared with the frequency in normal controls (luteal phase deficiency, 10.5 pulses/eight hours; normal, 5.2 pulses/eight hours; P less than or equal to .05). The mean FSH concentration was less in the women with luteal phase deficiency, but the level was not significant. These data suggest that the abnormal LH secretion pattern observed in women with luteal phase deficiency is responsible for their inadequate luteal phase progesterone secretion and their infertility. en_US
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject male contraception en_US
dc.subject andrology en_US
dc.subject 5-alpha reductase inhibitors en_US
dc.subject testosterone en_US
dc.subject gonadotropins en_US
dc.subject colchicine en_US
dc.subject klinefelter's syndrome en_US
dc.subject reifenstein's syndrome en_US
dc.subject spermatogenesis en_US
dc.subject.mesh Follicle Stimulating Hormone, secretion en_US
dc.subject.mesh Female en_US
dc.subject.mesh Infertility, Female, physiopathology en_US
dc.subject.mesh Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh Humans en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Luteinizing Hormone, deficiency, secretion en_US
dc.subject.mesh Biopsy en_US
dc.subject.mesh Corpus Luteum, physiopathology en_US
dc.subject.mesh Adult en_US
dc.title Abnormal patterns of pulsatile luteinizing hormone in women with luteal phase deficiency en_US
dc.type Article en_US


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