Galanin-like peptide as a link in the integration of metabolism and reproduction

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Galanin-like peptide as a link in the integration of metabolism and reproduction

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dc.contributor.author Steiner, Robert A. en_US
dc.contributor.author Gottsch, Michelle L. en_US
dc.contributor.author Clifton, Donald K. en_US
dc.date.accessioned 2008-10-17T20:42:24Z
dc.date.available 2008-10-17T20:42:24Z
dc.date.issued 2004-07 en_US
dc.identifier.citation Trends Endocrinol Metab. 2004 Jul;15(5):215-21 en_US
dc.identifier.uri http://hdl.handle.net/1773/4417
dc.description.abstract The arcuate nucleus is a hypothalamic center that couples energetics and reproduction. Peptide-releasing neurons in the arcuate nucleus receive and process humoral signals from the periphery and relay this information to other nuclei in the hypothalamus and preoptic area. Galanin-like peptide (GALP) is expressed in the arcuate nucleus, and GALP-containing neurons are targets for the action of leptin. GALP-containing neurons are closely apposed to gonadotropin-releasing hormone (GnRH) neurons in the preoptic area, and CNS injections of GALP stimulate GnRH-mediated secretion of luteinizing hormone. These observations indicate that GALP is a molecular signal that couples circulating indices of metabolism to the neuroendocrine reproductive system and, thus, regulates reproductive activity as a function of the energy state. In this article, we describe the involvement of GALP in metabolism and reproduction, and in the coupling between these two processes. en_US
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject arcuate nucleus en_US
dc.subject metabolism en_US
dc.subject reproduction en_US
dc.subject galanin-like peptide en_US
dc.subject.mesh Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh Galanin-Like Peptide, metabolism en_US
dc.subject.mesh Energy Metabolism, physiology en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Humans en_US
dc.subject.mesh Reproduction, physiology en_US
dc.title Galanin-like peptide as a link in the integration of metabolism and reproduction en_US
dc.type Article en_US


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