Variability of serum prolactin and progesterone levels in normal women: the relevance of single hormone measurements in the clinical setting

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Variability of serum prolactin and progesterone levels in normal women: the relevance of single hormone measurements in the clinical setting

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dc.contributor.author Cohen, Nancy L. en_US
dc.contributor.author Soules, Michael R. en_US
dc.contributor.author Fujimoto, Victor Y. en_US
dc.contributor.author Clifton, Donald K. en_US
dc.date.accessioned 2008-10-17T20:42:42Z
dc.date.available 2008-10-17T20:42:42Z
dc.date.issued 1990-07 en_US
dc.identifier.citation Obstet Gynecol. 1990 Jul;76(1):71-8 en_US
dc.identifier.uri http://hdl.handle.net/1773/4434
dc.description.abstract In order to delineate factors contributing to variation in hormone levels, progesterone and prolactin (PRL) levels from 28 normal women, obtained daily during one menstrual cycle and every 20 minutes during a midluteal 24-hour admission in a subgroup of five subjects, provided a data base for analysis of these variables. Pulsatile analysis of the 24-hour data was conducted using an adaptive-threshold algorithm, and normal reference ranges were generated from randomly selected daily hormone values. Our data verify that inherent variation can significantly alter single random serum levels of reproductive hormones. These variations included menstrual cycle day, circadian influence, pulsatile secretion, assay error, and biologic heterogeneity. Besides the expected day-to-day change in progesterone levels during the luteal phase, seven of ten women exhibited a significant circadian variation in progesterone; however, the time of day of the peak level was not consistent among women. Prolactin levels did not demonstrate any clinically relevant change over the menstrual cycle, but did have a consistent circadian pattern (nocturnal rise) over the 24-hour study period. Pulsatile variation occurred in both progesterone and PRL levels during the 24-hour admission. Five different reference ranges were generated from randomly selected single daily values from the 28 normal menstrual cycles. Although the mean levels calculated for each reference range were similar, the reference ranges demonstrated considerable variation due to the random sampling. In the five progesterone reference ranges, the lower limit of the range varied from 2.7-6.1 ng/mL, whereas the upper limit varied from 24.2-42.1 ng/mL.(ABSTRACT TRUNCATED AT 250 WORDS) en_US
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject prolactin en_US
dc.subject progesterone en_US
dc.subject female en_US
dc.subject single hormone values en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Menstrual Cycle, blood en_US
dc.subject.mesh Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh Circadian Rhythm, physiology en_US
dc.subject.mesh Prolactin, blood en_US
dc.subject.mesh Reference Values en_US
dc.subject.mesh Adult en_US
dc.subject.mesh Progesterone, blood en_US
dc.subject.mesh Female en_US
dc.subject.mesh Humans en_US
dc.title Variability of serum prolactin and progesterone levels in normal women: the relevance of single hormone measurements in the clinical setting en_US
dc.type Article en_US


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