The luteinizing hormone-releasing hormone pulse generator in men: abnormalities and clinical management

ResearchWorks/Manakin Repository

Search ResearchWorks


Advanced Search

Browse

My Account

Statistics

Related Information

The luteinizing hormone-releasing hormone pulse generator in men: abnormalities and clinical management

Show full item record

Title: The luteinizing hormone-releasing hormone pulse generator in men: abnormalities and clinical management
Author: Bremner, William J.; Sheckter, Carol B.; Matsumoto, Alvin M.; Gross, Kenneth M.
Abstract: Most men with hypogonadotropic eunuchoidism have absent luteinizing hormone and presumably absent luteinizing hormone-releasing hormone pulses. Pulsatile luteinizing hormone-releasing hormone therapy is effective in restoring normal gonadotropin secretion and testicular function and inducing fertility in men with hypogonadotropic eunuchoidism. Furthermore, pulsatile (versus continuous) luteinizing hormone-releasing stimulation of the pituitary gland is an absolute requirement for normal gonadotropin secretion. Men with idiopathic oligoazoospermia and selective elevation of follicle-stimulating hormone levels have slow luteinizing hormone and presumably luteinizing hormone-releasing pulse frequency. In these men, pulsatile luteinizing hormone--releasing treatment is effective in decreasing serum follicle-stimulating hormone levels, but it is unclear whether spermatogenesis and fertility are improved.
URI: http://hdl.handle.net/1773/4455

Files in this item

Files Size Format View
AmJObstetGyn_19 ... zing_Hormone_Releasing.pdf 151.3Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record