Luteal phase deficiency: abnormal gonadotropin and progesterone secretion patterns

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Luteal phase deficiency: abnormal gonadotropin and progesterone secretion patterns

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dc.contributor.author Bremner, William J. en_US
dc.contributor.author Cohen, Nancy L. en_US
dc.contributor.author Steiner, Robert A. en_US
dc.contributor.author Soules, Michael R. en_US
dc.contributor.author Clifton, Donald K. en_US
dc.date.accessioned 2008-10-17T20:43:37Z
dc.date.available 2008-10-17T20:43:37Z
dc.date.issued 1989-10 en_US
dc.identifier.citation J Clin Endocrinol Metab. 1989 Oct;69(4):813-20 en_US
dc.identifier.uri http://hdl.handle.net/1773/4476
dc.description.abstract Luteal phase deficiency (LPD) is a reproductive disorder associated with infertility and spontaneous abortion. This study was undertaken to determine whether LPD might be related to an abnormal pattern of gonadotropin secretion. We tested this hypothesis by evaluating the pattern of pulsatile LH secretion in both the follicular and luteal phases of the menstrual cycle in normal women (n = 21) and women with LPD (n = 20), which was diagnosed on the basis of two out of phase endometrial biopsies. In addition, we sought to determine whether changes in progesterone (P) pulse patterns could account for the decrease in average serum P levels in women with LPD. To this end, we examined the pulse patterns of P and compared these patterns between normal women and those with LPD. Frequent blood sampling was performed in both groups to determine their respective hormone secretion patterns. In the follicular phase, blood samples were obtained every 10 min for 12 h; in the luteal phase the samples were obtained every 10 min for 12 h; in the luteal LH, FSH, and P were assayed in each sample. Pulse detection was performed by an adaptive threshold method of pulse analysis. The LH pulse frequency was significantly higher in the women with LPD than in the normal women in the early follicular phase [P less than 0.05; LPD, 12.8 +/- 1.4 (+/- SE); normal, 8.2 +/- 0.7 pulses/12 h]. LH pulse frequency was similar in the early and late follicular phases in the women with LPD, whereas it was higher in the late follicular phase in normal women. Mean serum FSH levels were not different between groups in both the early and late follicular phases. In the luteal phase the P pulse amplitude and mean serum P level were significantly lower in the LPD group than in the normal women (P less than 0.01). We conclude that 1) a too rapid LH pulse pattern in the early follicular phase may lead to inadequate LH support of the corpus luteum and become manifest as LPD; 2) the mechanism for inadequate P secretion in LPD is decreased P pulse amplitude; 3) the finding of similar serum FSH levels in the two groups in both the early and late follicular phases did not support compromised folliculogenesis as an etiological factor for LPD. en_US
dc.language.iso en_US en_US
dc.publisher Endocrine Society en_US
dc.subject male contraception en_US
dc.subject andrology en_US
dc.subject gonadotropins en_US
dc.subject 5-alpha reductase inhibitors en_US
dc.subject spermatogenesis en_US
dc.subject testosterone en_US
dc.subject colchicine en_US
dc.subject klinefelter's syndrome en_US
dc.subject reifenstein's syndrome en_US
dc.subject.mesh Corpus Luteum, physiopathology en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Biopsy en_US
dc.subject.mesh Female en_US
dc.subject.mesh Galactorrhea, physiopathology en_US
dc.subject.mesh Endometrium, pathology en_US
dc.subject.mesh Menstrual Cycle en_US
dc.subject.mesh Humans en_US
dc.subject.mesh Infertility, Female, blood, physiopathology en_US
dc.subject.mesh Progesterone, blood, secretion en_US
dc.subject.mesh Follicle Stimulating Hormone, blood, secretion en_US
dc.subject.mesh Abortion, Habitual, blood, physiopathology en_US
dc.subject.mesh Adult en_US
dc.subject.mesh Luteinizing Hormone, blood, secretion en_US
dc.subject.mesh Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh Prolactin, blood en_US
dc.subject.mesh Pregnancy en_US
dc.title Luteal phase deficiency: abnormal gonadotropin and progesterone secretion patterns en_US
dc.type Article en_US


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