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Browsing Dissertations and Theses by Subject "Molecular and cellular biology"
Now showing items 21-40 of 182
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Characterization of Zika virus prevalence in Kenya and the innate antiviral type-I interferon response against infection
The recent unprecedented spread and severe pathogenic features of Zika virus (ZIKV) in the Americas have highlighted this emerging pathogen as a major threat to global public health. Substantial efforts have been devoted ... -
Characterizing cell state and cell fate by high-throughput single cell genomics
Animal development is one of the greatest sources of wonders in science. Development of multicellular organism is characterized by the differentiation of a fertilized egg into diverse cell types of the body in a programed ... -
Characterizing the molecular mechanisms of mitochondrial fusion and division in healthy and diseased cells
Balanced mitochondrial fusion and division activity in healthy cells typically establishes a reticular mitochondrial network that is able to support normal cellular activities. Disruptions in balanced mitochondrial dynamics ... -
Characterizing the Role of Histone Deacetylase 2 (HDAC2) in Mitochondria Function and Alzheimer’s Disease
Histone deacetylase 2 (HDAC2) is a major HDAC protein in the adult brain and has been shown to regulate many neuronal genes. The aberrant expression of HDAC2 and subsequent dysregulation of neuronal gene expression is ... -
Characterizing the Role of the Lateral Orbitofrontal Cortex in Risky Decision Making and Drug Taking behavior
Unnecessary risk-taking is a core characteristic of maladaptive behaviors such as addiction and gambling. Risk is defined as possible exposure to an unfavorable outcome which may include danger, loss, or harm. Engaging in ... -
Characterizing Transcriptional Activation of the Endoplasmic Reticulum Unfolded Protein Response in Caenorhabditis elegans Models of Tau Pathology
To endure over the organismal lifespan, neurons utilize multiple strategies to achieve protein homeostasis (proteostasis). Some homeostatic mechanisms act in a subcellular compartment-specific manner, but others exhibit ... -
Chromatin Remodeling Around Nucleosome Free Regions Represses Non-Coding RNA By DNA Looping and Transcription Factor Dependent Targeting of Isw2
(2013-02-25)The efficient three-dimensional packaging of DNA into eukaryotic nuclei is accomplished through spatially organizing and compacting DNA into chromatin. Maintaining proper access to DNA, by modulation of either the location ... -
Chromosome-specific maturation of the epigenome in the male germline of D. melanogaster
The male germline of Drosophila melanogaster is a powerful system for investigating chromatin regulation in a differentiating tissue. Testis-specific genes utilize a distinct system of gene activation, involving tissue-specific ... -
Cis-epigenetic control of developmental timing
Development of a single multipotent progenitor into distinct cell-types of the correct number and proportion requires careful coordination of gene expression patterns over time. Within the context of these complex gene ... -
Closely and Grossly: ESX-1 Mediated Membrane Disruption
Mycobacterium tuberculosis, the causative agent of Tuberculosis (TB), is an obligate human pathogen. Its ability to survive and spread is dependent upon its ability to survive within human hosts. The RD1 locus, which ... -
Complete mapping of HIV-1 escape from broadly neutralizing antibodies, vaccines, and drugs
The expansive global diversity of HIV-1 Env presents significant hurdles in developing a broadly protective vaccine. This diversity is a result of HIV Env’s exceptional evolutionary capacity, which allows it to evade the ... -
Computational Design and Optimization of Novel Subtype Specific Frizzled Binding Proteins for Modulation of Wnt Signaling
Wnt signaling is essential to a range of critical biologic processes including embryonic development, mature tissue maintenance, and cell proliferation. Dysregulation of the Wnt signaling pathway is conclusively implicated ... -
Controlling protein assembly on mineral surface with designed interfaces
Proteins that interface with inorganic crystals have critical functions in biology. For example, biomineralization proteins form hard tissues such as bone, abalone shell, and sponge spicules, and mineral binding proteins ... -
Coordination and regulation of bystander memory T cells
Memory T cells (Tmem) are best understood as highly specific killers, using their T cell receptor (TCR) to identify and rapidly eliminate infected or transformed cells. Although T¬mem are best understood through the lens ... -
Cullin5 and SOCS Protein Regulation of Receptor Tyrosine Kinases
Suppressors of cytokine signaling (SOCS) proteins are a family of eight proteins that can inhibit signal transduction through receptor tyrosine kinases (RTKs) by serving as substrate receptors in Cullin5-RING E3 ubiquitin ... -
Cytosolic RECONnaissance: Host Strategies for Sensing and Controlling Bacteria
Cyclic dinucleotides (CDNs) of bacterial and host origin mediate cytosolic immune responses through the stimulator of interferon genes (STING) signaling pathway, though evidence suggests alternative receptors exist. We ... -
dAKAP1: A mitochondrial AKAP that coordinates local translation
A-Kinase anchoring proteins (AKAPs) are a structurally diverse family of proteins defined by the ability to bind protein kinase A (PKA). AKAPs process and integrate a variety of intracellular signals by sequestering PKA ... -
De novo design of modular protein oligomers to investigate cell signaling
Clustering of receptors is a critical step in activation of signaling, but this phenomenon is difficult to investigate with native soluble ligands that bind only 1-2 copies of a receptor. I designed a series of modular ... -
De novo designed protein switches to enable increased specificity of targeted therapeutics
Targeted immunotherapies typically rely on the recognition of a single cell-surface marker, and as such, their specificity is limited and prone to incidentally harming healthy cells. This is problematic for developing ... -
Decoding the B cell receptor in endemic Burkitt Lymphoma: Insights into pathogenesis and implications for disease detection
The African endemic form of Burkitt Lymphoma (BL) is one of the most common pediatric malignancies in sub-Saharan Africa. BL is particularly prevalent in certain geographic regions, likely due to both environmental and ...