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Browsing Neuroscience by Title
Now showing items 61-80 of 117
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Mechanisms and treatments of drug consumption: A preclinical exploration in harm reducing pharmacotherapies for substance use disorders
The loss of control in amounts of drug consumed is a common trait experienced by persons living with drug addiction. The motivation of this dissertation is to further our understanding in the neural mechanisms that mediate ... -
Mechanosensory hair cell regeneration in the zebrafish lateral line is mitotic and facilitated by innervation
(2013-02-25)Mechanosensory hair cells in the inner ear are vulnerable to damage that can result in hearing loss and balance disorders. Exposure to excessive noise and ototoxic drugs are two of the leading causes of hair cell loss, ... -
Mesolimbic dopamine transmission during decisions involving cost-benefit tradeoffs
Real-world decisions frequently involve tradeoffs between multiple economic dimensions, and the integration of benefits and costs into a common currency of subjective value is fundamental to action selection. Phasic dopamine ... -
The metalloproteinase inhibitor Reck is essential for zebrafish DRG development
(2013-07-23)Embryonic development can be viewed as a series of fate choice events in which multipotent cells divide and adopt more specialized function and morphology. The vertebrate neural crest is an example of a multipotent cell ... -
Methods to promote reanimation and rehabilitation of forelimb function after spinal cord injury
Spinal cord injury is a devastating condition that can severely limit motor and sensory function and make an individual completely dependent on others for care. The effects of spinal cord injury are debilitating, and ... -
Microcircuitry of the songbird basal ganglia nucleus area X
Understanding learning is one of the most basic human fascinations. As a nation we devote large amounts of resources to discovering therapeutic interventions for and preventing learning disabilities that arise developmentally ... -
Microglia and astrocytoma cells express alkylindole-sensitive receptors
Two cannabinoid (CB) receptors, CB1 and CB2, have been identified at the molecular level. Evidence suggests that other cannabinoid and cannabinboid-like receptors remain to be identified. Using newly developed compounds, ... -
Microglia and astrocytoma cells express alkylindole-sensitive receptors
Two cannabinoid (CB) receptors, CB1 and CB2, have been identified at the molecular level. Evidence suggests that other cannabinoid and cannabinboid-like receptors remain to be identified. Using newly developed compounds, ... -
Mitochondria in the life and death of mechanosensory hair cells
Hair cells are mechanosensory receptors found in the inner ear that mediate hearing and balance. In humans, damage and death of these cells is an underlying cause of hearing loss. Given the high prevalence of hearing loss, ... -
Molecularly-defined cell types within the septal complex and their role in opioid dependence and withdrawal
Opioid withdrawal is an unpleasant experience and produces changes in pain, anxiety, depression, and general dysphoria. Because withdrawal is so intense, persons with opioid use disorder (OUD) often return to drug use to ... -
Monkey Hippocampal Neurons Track Ongoing Experiences
The hippocampus and surrounding structures of the medial temporal lobe are necessary for the formation of new episodic memories, that is, memories of experiences. It remains unclear, however, how neural activity within the ... -
Motion accumulates while movement disappears: spatial interactions in visual motion
(2014-04-30)When objects move, they change position over time. However, the mechanisms in human vision that could be capable of tracking these changes in position are not well understood. I constructed stimuli that combined a first-order ... -
Neural circuitry of retinal receptive fields in primate
(2007)The retina contains the first stages of the neural encoding of visual information that begins the generation of our perception of the visual world. The retina contains as many as 70 distinct cell types that interact in ... -
Neural Closed-loop Deep Brain Stimulation for Tremor Mitigation
Parkinson’s disease and essential tremor are two common neurodegenerative disorders affecting millions of individuals. The hallmarks of these diseases are their interference with normal movement, which can greatly affect ... -
Neural computation in the context of upstream dynamics in the retina
To understand neural circuit function, one would like to understand individual neurons' computation in the context of their physiological inputs. But these inputs are themselves subject to complex dynamics, and we rarely ... -
Neural encoding of object properties and task-dependent changes in primate visual area V4
Primates use vision to understand and interact with the world around them. Several interconnected visual areas are responsible for processing information about visual objects, ultimately enabling object and scene recognition ... -
Neural mechanisms for decisions based on sequential samples of evidence
Difficult decisions often require evaluation of samples of evidence that are acquired sequentially. If samples of evidence differ in their reliability and an unlimited number of samples can be acquired sequentially, the ... -
Neural Pathways Integrating Circadian Information into the Decision to Trigger Ovulation
(2012-09-13)It has long been known that time-of-day information is required for successful initiation of the ovulation-triggering luteinizing hormone (LH) surge. This is true in rodents and evidence suggests it is true in humans too. ... -
Neural Representation of Economic Parameters by Dopamine Release: a Quantitative Analysis
(2013-04-17)The goal of the field of neuroeconomics is to understand the neural representations of variables relevant to theories of decision-making. These variables include the expected value of a prospect and the uncertainty ... -
Neuronal and Network-based Mechanisms of Spontaneous Synchronous Activity in the Developing Mouse Cortex
Spontaneous synchronous activity (SSA) that propagates as electrical waves is found in numerous CNS structures and is critical for normal development, but the mechanisms of generation of such activity are not clear. In ...