The system will be down for regular maintenance from 8:00-10:00am PDT on April 3rd, 2024.
Search
Now showing items 1-10 of 117
Dissociable Cost and Benefit Encoding of Future Rewards by Mesolimbic Dopamine
(University of Washington Graduate School, 2011-08-01)
Dopamine is a neural substrate implicated in the complex computation of weighing the costs and benefits of future actions. Midbrain dopamine neurons encode fundamental economic parameters pertaining to predicted rewards in their subsecond firing pattern and innervate areas that have been implicated in economic decision-making ...
Brain-Based Individual Difference Measures of Reading Skill in Deaf and Hearing Adults
A majority of deaf students leave high school reading at or below a fourth grade level, but some deaf individuals do become highly proficient readers. There is disagreement about the causes of this reading difficulty, and by association, disagreement about the effectiveness of different strategies for teaching reading to deaf ...
We must inspire before we expire
For mammals, breathing is essential for life and is composed of three phases: inspiration, postinspiration, and active expiration. The networks that generate the three phases are distributed bilaterally and rostrocaudally along the ventral lateral medulla of the brainstem, and are collectively referred to as the ventral ...
Facilitating the incorporation of neuroscience methods and knowledge into brain-computer interfaces
This body of work is focused on brain-computer interfaces (BCIs) – devices that interpret brain activity in order to generate artificial output. BCIs have a great deal of promise in both rehabilitative and commercial domains. However, there is still a list of obstacles that must be solved before BCIs can advance out of ...
Acute regulation of synaptic NMDA receptor content in hippocampal neurons
Hippocampal-dependent learning, which is required for forming fact-based, declarative memories, involves changing the physical and functional characteristics of connections between neurons, called synapses. This process of “synaptic plasticity” is mediated by the N-methyl-D-aspartate receptor (NMDAR). NMDARs are ionotropic ...
The role of the FEFsem in smooth pursuit: Insights from varying retinal input
Primates are exceptionally adept at tracking moving objects with their eyes, providing high-acuity vision throughout the duration of tracking. This behavior, called smooth pursuit, relies on incoming visual signals being successfully transformed into eye movement commands. Though a seemingly simple process, in practice this ...
The role of muscarinic cholinergic signaling in cost-benefit decision making
Animals regularly face decisions that affect both their immediate success and long term survival. Such decisions typically involve some form of cost-benefit analysis and engage a number of high level cognitive processes, including learning, memory and motivational influences. While decision making has been a focus of study ...
The ins of the striatum: Utilizing chemogenetics to define the contribution of cortical and thalamic afferents during addiction behaviors
Addiction is a chronic neuropsychiatric disorder accompanied by high rates of recidivism that lacks effect treatment, part of which may be due to an incomplete understanding of the brain circuits mediating addiction. Cortico-basal ganglia circuitry is a complex, interconnected network regulating addiction. Aberrant glutamatergic ...
Development and regeneration of neuronal circuits in the vertebrate retina
Like in other parts of the central nervous system (CNS), information processing in the retina depends upon the exquisite organization of synaptic connectivity amongst diverse neuronal cell types. Assembly of neuronal circuits during retinal development is highly orchestrated. Recapitulating the precision of this process ...
Development, generation, and origin of synchronous oscillations in the brainstem respiratory network
(2006)
Neurons within the intact respiratory network are synchronized on long and short time scales to generate respiratory rhythm and synchronous oscillations in spike firing during inspiration (Figure 1.1), respectively. Such oscillations shape the pattern of inspiratory activity that leads to contractions of the inspiratory ...