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Browsing Bioengineering by Title
Now showing items 78-97 of 356
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Designing the diffusion immunoassay (DIA): how properties of the analyte affect DIA performance
(2007)The diffusion immunoassay (DIA) is a novel assay technique based on the difference in diffusivity of an analyte molecule when free in solution, versus when it is bound to a cognate antibody. It is uniquely enabled by the ... -
Determination of alpha-sheet secondary structure as an early biomarker in the pathogenesis of Alzheimer's disease
Alzheimer’s disease (AD) is one of over 50 amyloid diseases discovered to-date and is now the sixth leading cause of death in the United States, affecting over 5.8 million Americans and projected to cost upwards of $1.1 ... -
Determining the feasibility of assessing the adequacy and immunophenotype of human breast core needle biopsies using molecular and H&E fluorescence imaging via deep-UV optical microscopy
Histopathology techniques have not advanced with related technological innovations made in the last few decades. As a result, they are needlessly time consuming, labor intensive, and are not adapted for core needle biopsies ... -
Developing a FRET tension sensor-compatible system for analyzing cardiomyocyte tension alongside applied strain
Cardiomyopathy refers to heart diseases in which myocardial tissue has undergone structural changes, often resulting in systolic dysfunction. Restructuring of the heart is influenced by mechanical forces and these organ-level ... -
Developing a library of recognition proteins using FimH as a protein scaffold
(2013-11-14)High specificity recognition proteins, like antibodies, are important biological tools with many applications, including diagnostics, therapeutics, and imaging. However, there are many challenges with antibody recognition ... -
Developing an Inducible Osteoclast System as a Cell Therapy for Ectopic Calcification
Ectopic calcification (EC) is a complex disease in which mineral develops in abnormal locations. It can develop in a variety of locations throughout the body, including the vasculature, heart valves, and in orthopedic ... -
Developing and Validating Novel Genetically Encoded Sensors in Animal Behavioral Models to Investigate KOR-Dynorphin Interactions
Deaths from the opioid epidemic have been increasing steadily in recent years and have prompted many studies investigating various neural circuits related to addiction. Previous work has shown that both κ-opioid receptor ... -
Development and Application of Augmented Smartphone-enabled Imaging in Mobile Health
Mobile health techniques aim to deliver healthcare remotely and wirelessly using surging computing power and mobile connectivity. The commercial smartphone is naturally becoming a popular partner device due to its ... -
Development and Application of Multifunctional Optical Coherence Tomography
Microcirculation refers to the functions of capillaries and the neighboring lymphatic vessels. It plays a vital role in the pathophysiology of disorders in many clinical areas including cardiology, dermatology, neurology ... -
Development and Application of Multifunctional Optical Coherence Tomography
Microcirculation refers to the functions of capillaries and the neighboring lymphatic vessels. It plays a vital role in the pathophysiology of disorders in many clinical areas including cardiology, dermatology, neurology ... -
Development and Application of Polarization Sensitive Optical Coherence Tomography
Optical coherence tomography (OCT), a three-dimensional optical imaging technique based on low coherence interferometry, can be extended to measure the functional property of the biological sample. As a functional extension ... -
Development and Investigation of a Dihydroartemisinin-Resistant Human Leukemia Cell Line
Artemisinin generates cytotoxic free radicals when it reacts with ferrous iron, and induces molecular damages and apoptosis in cells. Its toxicity is more selective toward cancer cells because cancer cells contain a higher ... -
Development and Optimization of Peptide-Based, Tumor-Associated Macrophage (TAM)-Targeting Therapeutics
Cancer is one of the leading causes of death and is a subject of intense research worldwide. Within the past few decades, cancer immunotherapy has emerged as an important arm of cancer therapies following the prominent ... -
Development of a Field-Use Paper-Based PKU Test Using Colorimetric Readout
Current newborn screening programs for phenylketonuria (PKU) do not reach many individuals, worldwide, who would benefit from testing. Existing PKU tests require a high-resource laboratory, as well as a base level of local ... -
Development of a Highly Sensitive Protein Diagnostic Device using Isothermal Strand Displacement Amplification
The lateral flow test (LFT) is the preferred tool for detection of protein biomarkers in low-resource settings. While low-cost and rapid, these immunoassay devices often suffer from limited sensitivity in the single chemical ... -
The development of a multi-model optical imaging system to investigate hemodynamic responses to tissue injury in vivo
(2014-04-30)Ischemic injury is caused by blockage or rupture of a blood vessel supplying an organ with oxygen and nutrients. A reduction of blood flow in the brain below critical values leads to a series of metabolic, functional, and ... -
Development of a Non-Instrumented Point-of-Care (POC) HIV-1 Diagnostic Device
(2013-11-14)There is a growing need for sensitive, simple, affordable and rapid detection of infectious disease biomarkers for faster access to test results and improved patient outcomes. The development of rapid, portable and accurate ... -
Development of a Novel Paper-Based Flu Test for Improved Diagnosis at the Point of Care
The development of paper-based diagnostics has surged in recent years, due to the suitability of these tests for use at the point of care. Paper-based diagnostics offer the ability to perform relatively sophisticated ... -
Development of activatable recognition proteins using the bacterial adhesin FimH
Recognition molecules, such as antibodies, are widely useful in many applications within bioengineering, or life sciences in general. However, the high cost and variability in antibodies has led to the development of ... -
Development of biomaterial porous scaffolds for dendritic cell modulation and mRNA delivery
mRNA has emerged as a potential candidate for vaccine applications in recent years as a versatile, safe, and cost-effective alternative to traditional therapeutics. Efficient delivery to antigen presenting cells and ...