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Browsing Bioengineering by Title
Now showing items 259-278 of 356
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On the Auxiliary Driving Mechanism for Blood Circulation
This thesis discusses a driving mechanism for blood circulation over and above the pressure gradient. Fluid commonly flows in response to an external pressure gradient. However, when a tunnel-containing hydrogel is immersed ... -
Oncoslice: A Microfluidic Platform for Personalized Cancer Care and Drug Development
Improving efficacy, minimizing the adverse side effects of drugs, and overcoming acquired resistance to drug treatment have been major goals and emphases in cancer therapy. Existing models of drug activity (based on tumor ... -
Ophthalmic Application of Optical Coherence Tomography Angiography for Retina and Choroidal Imaging
Optical coherence tomography (OCT) angiography (OCTA) is a revolutionary non- invasive imaging modality that has been widely utilized in ophthalmology. OCT and OCTA has huge potentials for quantitative analysis based on ... -
Ophthalmic Application of Optical Coherence Tomography Based Angiography for Choroidal Imaging
We demonstrated in vivo choriocapillaris imaging in normal human subjects with a Cirrus HD 5000 spectral domain OCT prototype. With the tracking system installed in the prototype and the montage scanning protocol, wide ... -
Optical coherence tomography for quantitative analyses of cerebral vessel morphology and hemodynamics
The brain plays a crucial role in life-sustaining activities of human, including consciousness, logical thinking, emotional feeling, memory storage, somatic movement, and communication. As the most complex but least ... -
Optical Coherence Tomography for the Assessment of Skin Adaptation to Repetitive Mechanical Stress
Skin breakdown is a problem that affects many individuals with lower limb loss. Breakdown is caused most commonly by repetitive mechanical stresses that are imposed on the residual limb at its interface with the prosthetic ... -
Optical Mapping of Human Embryonic Stem Cell-Derived Cardiomyocyte Graft Electrical Activity in Injured Hearts
Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) show tremendous promise for cardiac repair. hESC-CMs can be efficiently generated in high numbers for cardiac transplantation, have been shown to form stable ... -
Optimizing Markerless Motion Tracking for the Study of Hand Kinematics
To facilitate studies investigating motor movements and learning mechanisms involved in complex kinematic tasks, there is need for effective real time 3D motion tracking. Current methodologies for motion tracking are ... -
Patient-Specific Guides: Improved Point-Registration Accuracy for Surgical Navigation and Robotic-Assisted Surgery
Image-based surgical navigation offers improved integration of preoperative planning with intraoperative execution and documentation. Registration is a fundamental step in all surgical navigation procedures and entails the ... -
Peptide-functionalized Biomaterials for Hemostasis and Cancer Imaging
Molecular recognition drives all biological processes and can be leveraged to engineer a broad range of biomaterials for detection and treatment of altered states in the body. Part I of this dissertation focuses on the use ... -
pH-responsive polymers for nucleic acid and vaccine delivery
Biomacromolecules such as nucleic acids and peptides have great potential as therapeutics but must overcome many challenging biological barriers to succeed in the clinic. In this work, we present several investigations of ... -
Phase Sensitive MRI and its Application to Cardiovascular Diseases
Inversion recovery phase sensitive (IRPS) imaging is a T1 weighted magnetic resonance imaging(MRI) method and its T1 contrast is introduced by a $180^{o}$ radio frequency(RF) pulse. IRPS image keeps the polarity map and ... -
Photo-switching of protein activities by conjugation of photo-responsive polymers to proteins
(2001)Photo-switching of protein functions has recently become more actively investigated by many researchers. Our objective is to create novel photo-switchable proteins by conjugating photo-responsive polymers to proteins ... -
Physical and computational methods of investigating the relationship between stress, cognition, and behavior in the context of the KOR-dynorphin system
Motivation: Chronic stress is an aversive experience that can have maladaptive effects on an individual’s cognition and behavior, ultimately leading to increased risk of developing conditions such as anxiety, depression, ... -
Physiological and Mechanical Effects of Prosthetic Elevated Vacuum Systems in People with Transtibial Amputation
A major problem among people with a lower limb amputation is maintaining socket fit. Long-term and short-term changes of residual limb volume can alter socket fit resulting in pain, skin breakdown, or falls. Several ... -
Polymerase Engineering to Expand Access to Nucleic Acid Diagnostics and Technologies
Diagnostic and molecular biology workflows are often complex when first developed, and simplifying them is a key step in expanding their use from high-resource labs to low-resource settings such as clinics and developing ... -
Polymerizable Peptide Monomers for the Targeted and Intracellular Delivery of Cancer Therapeutics
For the treatment of cancer, peptides hold great potential as both targeting and therapeutic agents. One particularly promising anti-cancer strategy is peptides derived from the third Bcl-2 homology domain (BH3), which ... -
Porous membranes for interfacing microfluidics with cell cultures
(2013-11-14)The sensing of chemical gradients plays an important role in the guidance of cells for tissue development, migration of cells in the immune system, and human disease. We have developed a microfluidic transwell insert for ... -
Porous Template Scaffolds as a Three-Dimensional Culture Platform for Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) have been investigated for therapeutic applications due to their regenerative and immunomodulatory properties. While the cells show promise for eventual clinical translation, barriers remain ... -
Predicting expression levels of de novo protein designs in yeast through machine learning.
Protein engineering has unlocked potential for the biomolecular synthesis of amino acid sequences with specified functions. With the many implications in enhancing therapy development, developing accurate functional models ...