Browsing Bioengineering by Issue Date
Now showing items 1-20 of 356
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Lipid binding from aqueous solution by lipid conjugated hydroxypropyl methylcellulose (HPMC): a novel food additive for reducing cholesterol and fat intestinal absorption
(1988)This research project focuses on the development and testing of a novel, medically useful lipid or steroid sequesterant that can be administered orally. Specifically, this compound is designed to absorb cholesterol and ... -
Macrophage interactions with biomaterial surfaces and their effects on endothelial cell activation
(1998)This research project focused on the development of in vitro models to study cell reactions with material surfaces and how materials exert their influence on cell-cell interactions. Macrophage inflammatory cytokine release ... -
Molecular recognition in the streptavidin-biotin system
(1998)In this project, the bases for high-affinity interaction and ligand recognition were investigated in the streptavidin-biotin system. With an estimated binding constant on the order of 1013 M-1, the binding of biotin to ... -
Molecular diversity and evolution of human immunodeficiency virus type 1
(1999)HIV-1 is a rapidly evolving virus that has infected tens of millions of individuals throughout the world. Studies on HIV-1 are described various aspects of viral evolution, however, many questions concerning the evolution ... -
Artificial muscles: actuators for biorobotic systems
(1999)Biorobotic research seeks to develop new robotic technologies based on the performance of human and animal neuromuscular systems. The development of one component of a biorobotic system, an artificial muscle and tendon, ... -
An integrated optical microcalorimeter
(1999)Microcalorimetry is the detection and quantification of small changes of heat in a system. Interferometry as a measuring technique is known for its high degree of sensitivity. Bulk optical interferometry is impractical for ... -
Endothelial cell interactions with model surfaces: effect of surface chemistry, surface mobility, and the adsorbed protein layer
(1999)The clinical success of the small diameter vascular graft remains limited due to occlusion resulting from thrombus formation. Methods for promoting graft endothelialization have been investigated to improve graft healing. ... -
Analysis of defibrillation efficacy and investigation of impedance cardiography with finite element models incorporating anisotropic myocardium
(1999)Increasing defibrillation efficacy by estimating and lowering the defibrillation threshold (DFT) is important in positioning implantable defibrillating electrodes. We analyzed the relation between the experimentally-measured ... -
Control of protein activities by conjugation of stimuli-responsive polymers to proteins
(2000)Streptavidin binds biotin with an extraordinary affinity (Ka = 1013--15 M-1). This unique property has found widespread applications in biotechnology fields. However, its application in affinity separation is limited because ... -
An investigaton of the mechanisms of high intensity focused ultrasound induced platelet activity
(2001)The goal of the acoustic hemostasis project is to locate a hemorrhage using diagnostic ultrasound and halt the bleeding using high intensity focused ultrasound (HIFU). To enhance the imaging of blood, the use of ultrasound ... -
Growth and function of transgenic endocrine cells on silanized surfaces
(2001)Interactions of transplantable cells with synthetic polymers might influence the function of biohybrid artificial organs. This study explored growth and secretion of human insulin by transgenic betaG I/17 insulinoma cells ... -
Medical ultrasound algorithm for noninvasive high intensity ultrasound applications
(2001)In order to simulate ultrasound propagation and subsequent thermal effects in biological media in which blood vessels and other structures may be present, a 3-dimensional model has been developed that eliminates the need ... -
Molecular modeling of the bacterial chemotaxis receptors Tar and Trg
(2001)Bacterial chemotaxis receptors signal across the membrane by a conformational change that traverses their periplasmic, transmembrane, and cytoplasmic domains. The mechanism of this conformational change is controversial ... -
Photo-switching of protein activities by conjugation of photo-responsive polymers to proteins
(2001)Photo-switching of protein functions has recently become more actively investigated by many researchers. Our objective is to create novel photo-switchable proteins by conjugating photo-responsive polymers to proteins ... -
Fluorescence anisotropy near-field scanning optical microscopy (FANSOM): a new technique for biological microviscometry
(2001)To test hypotheses regarding putative roles of water structuring in cell function, a near-field scanning optical microscope system was implemented and adapted for nano-scale fluorescence anisotropy measurement. Technical ... -
Spatially controlled engineering of myocardial tissue
(2001)Developmental biology and tissue regeneration processes utilize specific spatial adhesive cues to direct the assembly of cells into complex, organized tissues. Microfabrication methods provide analogous technologies to ... -
Compressive cervical spine injury: the effect of injury mechanism on structural injury pattern and neurologic injury potential
(2002)Cervical spine trauma resulting in spinal cord injury is a particularly devastating musculoskeletal injury. Every year thousands of individuals are added to the ranks of those afflicted by it. And, the associated socioeconomic ... -
Spina accresco mechanicus: on the developmental biomechanics of the spine
(2002)Epidemiological data and clinical indicia reveal devastating consequences associated with pediatric neck injuries. Neither injury prevention nor clinical management strategies will be able to effectively reduce these effects ... -
A model for microcirculatory fluid and solute exchange in the heart
(2002)The exchange of fluids and solutes across the capillary wall is necessary to sustain multicellular life. Although the basic physiology of these processes is understood qualitatively, predicting the detailed kinetics of ... -
Temperature-dependant [sic] smart bead adhesion: a versatile platform for biomolecular immobilization in microfluidic devices
(2003)Microfluidic systems for chemical and biochemical analysis promise increased process portability, speed, and efficiency as well as decreased waste. One important aspect of microfluidic design is the incorporation of ...