Browsing Bioengineering by Author "Kim, Deok-Ho"
Now showing items 1-10 of 10
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A Nanopatterned Cantilever Device for Assaying Contractile Properties of Stem Cell-Derived Cardiomyocytes
Lih, Daniel ChenDrug-induced cardiotoxicity has been a major issue for both patients and pharmaceutical companies. Current in vitro cardiotoxicity screening utilizes genetically modified cell lines, which do not recapitulate adult human ... -
Bioprinting 3-Dimensional Skeletal Muscle Tissue Models Using Decellularized Extracellular Matrix
Nawas, Zeid YousefDeveloping biologically relevant models of human tissues and organs is an important enabling step for many applications within biological research and medicine. A specific application that physiologically relevant tissue ... -
Combinatorial maturation strategy for disease modeling and phenotypic drug screening of Duchenne muscular dystrophy cardiomyopathy
Macadangdang, Jesse RadcliffHuman pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) offer great promise for regenerative medicine, preclinical drug screening, and cardiac disease modeling applications. One of the most significant hurdles towards ... -
Correlation-Based Contraction Tracking of Cardiomyocyte Monolayers
Frankel, SamuelCardiac tissue engineering has made great strides in combating cardiovascular disease in modern society utilizing cardiac regenerative medicine as well as in vitro disease modeling. Stem cell-derived cardiomyocytes are a ... -
Effects of Nanotopography on Structural Maturation and Differentiation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Leung, Winnie Wing-YinHeart diseases remain the leading cause of morbidity and mortality worldwide. As damages done to the heart are irreversible, heart transplant is the ultimate therapy, but it is greatly limited by the shortage of heart ... -
Engineering Combinatorial Microenvironments for Structural and Functional Maturation of Human Stem Cell-Derived Cardiomyocytes
Carson, Daniel (2014-02-24)As cardiovascular disease remains to be the leading cause of death worldwide, cardiac regenerative medicine aims to apply design methods to develop functional cardiac tissue for directed therapy as well as <italic>in ... -
Engineering of Functional, Striated Muscle Tissues with Controllable 3D Architectures Using a Novel, Thermoresponsive, Nanofabricated Substratum
Jiao, AlexMost tissues in the human body demonstrate multiscale organization, from extracellular matrix (ECM) structure, to cell morphologies, to overall tissue architecture. Further, in the cases of cardiac and skeletal muscle, ... -
Engineering post-infarct extracellular matrix remodeling in vitro for understanding cardiac fibroblast fate and function
Kim, PeterMyocardial fibrosis is associated with vast majority of cardiovascular diseases which is one of the most common disease afflicting adults around the world. During myocardial infarction, myocytes die and are replaced by a ... -
Multiscale Tunable Hybrid Biomaterials for Engineering Human iPSC-Based Cardiac Microphysiological Systems
Tsui, JonathanHuman induced pluripotent stem cells (hiPSCs) offer tremendous potential for use in engineering human tissues for disease modeling, drug development, and cell therapy. However, differentiated cardiomyocytes are phenotypically ... -
Tissue-Engineered Arterial Tunica Media with Multi-layered, Circumferentially Aligned Smooth Muscle Architecture
Yan, Shi Ying CalystaBlood vessels play an important role in drug screening in terms of permeability and control of blood flow through cellular responses. Three distinctive functional layers make up the architecture of blood vessels, including ...