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Structural and biochemical studies of protein poly(ADP-ribosyl)ation
(2013-04-17)
Protein poly(ADP-ribosyl)ation (PARylation) has been found to be involved in various cellular processes, such as DNA damage recognition and repair, chromatin structure dynamics, gene transcription and poly(ADP-ribose)-dependent cell death. Most recently, PARylation has been shown to control the polyubiquitination and degradation ...
Regulation of retinal endothelial cells and pericytes by VEGF, TGF-beta1, and SPARC
(1998)
Ocular diseases characterized by retinal neovascularization are among the principal causes of visual loss worldwide. In an effort to understand the components of the retinal angiogenesis and its regulation by various molecules, I developed a procedure to isolate retinal microvascular endothelial cells (EC) and pericytes from ...
Cell adhesion molecules in human hair follicle morphogenesis
(1996)
Hair follicle formation in fetal development is characterized morphologically by invagination and elongation into the dermis of an epidermal cell collective in association with a follicle-specific population of mesenchymal cells. The process is thought to involve cell proliferation and migration, mediated by molecules such ...
Notch signaling in cell-fate specification and maintenance in the developing and adult mammalian inner ear
(2009)
The inner ear contains the auditory and vestibular organs, which are sensory neuroepithelia composed of mechanosensory hair cells and glia-like supporting cells. The mammalian auditory sensory epithelium, the organ of
Corti, is responsible for transduction of sound stimuli into electrical signals for hearing function. Hair ...
An ancient neurotrophin code in zebrafish; the Runx/Cbfβ complex specifies the fate switch from TrkB+ to TrkC+ nociceptors and sensory receptor expression
The somatosensory system is a critical interface to the environment. It contains a highly diverse group of sensory neurons that are responsible for sensing touch, temperature, pain, and proprioception. The Runx transcription factors have been identified as key factors in generating some somatosensory neuron diversity. However, ...
The role of V4 in object motion processing
We rely heavily on our visual system for many functions. More specifically, the ability to process and track moving objects is of utmost importance. Much of the literature and conventional teachings in neuroscience hypothesize that the visual system has two functionally distinct pathways: a dorsal visual pathway for motion ...