Browsing by Subject "Animals"
Now showing items 1-20 of 101
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Absence of germline infection in male mice following intraventricular injection of adenovirus
(Elsevier, 2001-12)The possibility of inadvertent exposure of gonadal tissue to gene therapy vectors has raised safety concerns about germline infection. We show here that the receptor for coxsackie B viruses and adenoviruses ... -
Activation of the sympathetic nervous system by galanin-like peptide--a possible link between leptin and metabolism
(Endocrine Society, 2003-11)The effects of leptin upon body weight (BW) cannot be explained by its anorectic actions alone. Part of the metabolic changes elicited by leptin includes sympathetic nervous system activation leading to ... -
Activation-dependent regulation of galanin gene expression in gonadotropin-releasing hormone neurons in the female rat [see comments]
(Endocrine Society, 1994-05)In rats, galanin is colocalized in GnRH neurons, and galanin mRNA in GnRH neurons is increased coincidentally with the preovulatory gonadotropin surge. Whether the induction of galanin mRNA in GnRH neurons ... -
Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids
(Company Of Biologists Limited, 2004-01)Androgen receptor function is required for male embryonic sexual differentiation, pubertal development and the regulation of spermatogenesis in mammals. During spermatogenesis, this requirement is ... -
An automated technique for the radiographic determination of bone age
(Blackwell Publishing, 1982)We have developed an automated procedure for determining bone-age in the monkey, Macaca fascicularis. The status of epiphysial junctions and sesamoids were determined from radiographs. Epiphyses were scored ... -
The central role of Sertoli cells in spermatogenesis
(Elsevier, 1998-08)Sertoli cells are the somatic cells of the testis that are essential for testis formation and spermatogenesis. Sertoli cells facilitate the progression of germ cells to spermatozoa via direct contact and by ... -
Cloning and characterization of the mouse interleukin enhancer binding factor 3 (Ilf3) homolog in a screen for RNA binding proteins
(Springer-Verlag, 1999-05)In a screen for RNA-binding proteins expressed during murine spermatogenesis, we have identified a cDNA that encodes a protein of 911 amino acids that contains two copies of the double-stranded RNA-binding ... -
Cloning and distribution of galanin-like peptide mRNA in the hypothalamus and pituitary of the macaque
(Endocrine Society, 2002-03)Galanin-like peptide (GALP) is a newly discovered hypothalamic neuropeptide, which is regulated by leptin and implicated in the regulation of GnRH secretion in the rodent. We searched the human genome ... -
Clusterin in the male reproductive system: localization and possible function
(Elsevier, 1999-05-25)Clusterin is a glycoprotein that was initially isolated from the male reproductive system. Subsequently, clusterin has been found to be widely distributed in a variety of tissues in mammals. One characteristic ... -
Differential patterns of Fos induction in the hypothalamus of the rat following central injections of galanin-like peptide and galanin
(Endocrine Society, 2003-04)Galanin and its newly discovered relative galanin-like peptide (GALP) are neuropeptides that are implicated in the neuroendocrine regulation of body weight and reproduction. GALP has been shown to bind in ... -
Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse
(Endocrine Society, 2005-07)Kisspeptins are products of the Kiss1 gene, which bind to GPR54, a G protein-coupled receptor. Kisspeptins and GPR54 have been implicated in the neuroendocrine regulation of GnRH secretion. To test the ... -
Diminished luteinizing hormone pulse frequency and amplitude with aging in the male rat
(Endocrine Society, 1983-03)Aging in the male rat is associated with a reduction in circulating testosterone levels. One possible cause of this decline is an age-related alteration of central nervous system-mediated LH secretion. To ... -
Distribution and regulation of galanin receptor 1 messenger RNA in the forebrain of wild type and galanin-transgenic mice
(Endocrine Society, 2003)To learn more about molecular alterations in the brain that occur as a consequence of either the chronic excess or absence of peptide neurotransmitters, we examined the impact of genetically manipulating the ... -
Distribution and regulation of galanin-like peptide (GALP) in the hypothalamus of the mouse
(Endocrine Society, 2001-12)Galanin-like peptide (GALP) is a newly discovered molecule whose expression in the brain is confined to the arcuate nucleus and median eminence. In the rat, cellular levels of GALP mRNA are reduced by fasting ... -
Distribution of galanin messenger RNA-expressing cells in murine brain and their regulation by leptin in regions of the hypothalamus
(Elsevier, 2001)Galanin is widely distributed throughout the mammalian brain and has been implicated in the regulation of food intake, metabolism and reproduction-functions that are also thought to be under the control of ... -
A double-stranded RNA binding protein required for activation of repressed messages in mammalian germ cells
(Nature Publishing Group, 1999-06)Chromatin packaging in mammalian spermatozoa requires an ordered replacement of the somatic histones by two classes of spermatid-specific basic proteins, the transition proteins and the protamines. Temporal ... -
Ectopic galanin expression and normal galanin receptor 2 and galanin receptor 3 mRNA levels in the forebrain of galanin transgenic mice
(Elsevier, 2005)The functional interactions of the neuropeptide galanin (GAL) occur through its binding to three G protein-coupled receptor subtypes: galanin receptor (GALR) 1, GALR2 and GALR3. Previously, we demonstrated ... -
Effect of CGS 20267 on ovarian aromatase and gonadotropin levels in the rat
(Springer Verlag, 1998-03)Aromatase catalyzes the rate limiting step that converts androgens to estrogens. Postmenopausal women with hormone dependent breast cancer respond to first generation aromatase inhibitors such as aminoglutethimide ... -
The effect of testicular x-irradiation on spermatogenesis in man. A comparison with the mouse
(American Society of Andrology, 1983-11)Existing data concerning the effects of x-irradiation on spermatogenesis in man were analyzed and the results were compared to published data on the mouse. Testicular x-irradiation produced a transient, but ... -
Effects of castration and recombinant human inhibin administration on circulating levels of inhibin and gonadotropins in adult male monkeys
(American Society of Andrology, 1994-03)Inhibin has been suggested to play a role in gonadal feedback regulation of follicle-stimulating hormone (FSH) secretion; however, neither the half-life nor the time course of action of recombinant inhibin ...