Browsing by Author "Daggett, Valerie"
Now showing items 1-8 of 8
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Biophysical strategies to inhibit bacterial amyloid formation and undermine biofilm infections
Bleem, AlissaWhen bacteria dwell in biofilms on the surface of an implanted medical device or surgical site, cells co-associate using a self-produced extracellular matrix (EM), which acts as a layer of protection against antibiotic ... -
Data-driven Methods and Models for Predicting Protein Structure using Dynamic Fragments and Rotamers
Rysavy, Steven J. (2014-04-30)Proteins play critical roles in cellular processes. A protein's conformation directly relates to its biological function and, consequently, determination of such structure can provide great insight into a protein's function. ... -
Determination of alpha-sheet secondary structure as an early biomarker in the pathogenesis of Alzheimer's disease
Shea, DylanAlzheimer’s disease (AD) is one of over 50 amyloid diseases discovered to-date and is now the sixth leading cause of death in the United States, affecting over 5.8 million Americans and projected to cost upwards of $1.1 ... -
The Development of Tools to Investigate Relationships between Atomic Contacts in Proteins
Su, Robert (2014-02-24)The time-varying states of atomic contacts reflect the dynamics of the protein. Protein dynamics are linked to protein functions. Thus, it is crucial to have automatic methods for extracting the relationships between atomic ... -
The Dynamics and Folding Pathways of Naturally Occurring and Engineered Proteins at Atomic Resolution
McCully, Michelle E. (2013-02-25)The protein folding problem, the aim to understand how a protein’s amino acid sequence alone is sufficient to dictate its folded structure in a given environment, has confounded scientists for decades. Comprehensive ... -
THE DYNAMICS AND MISFOLDING PATHWAYS OF THE PRION PROTEIN AT ATOMIC RESOLUTION
Cheng, Chin JungPrion diseases are fatal, transmissible and incurable neurodegenerative diseases that only infect mammals. While the manifestation of prion disease is not completely understood, it is known that the prion protein (PrP) ... -
Modelling pathological conformations in transthyretin amyloidosis
Childers, Matthew CarterThe amyloidoses are a set of fatal disorders in which proteins aggregate and form fibrils that deposit in tissues throughout the body. Amyloid diseases are challenging to study as critical events in amyloid formation occur ... -
The Role of α-Sheet Structure in Bacterial and Mammalian Amyloidogenesis and its Implication in the Microbial Alzheimer’s Disease Hypothesis
Prosswimmer, Tatum SoleilMammalian amyloidogenesis is implicated in over 50 diseases and its formation is typically considered inherently pathological. Conversely, many bacteria utilize amyloid fibrils as a structural scaffold to fortify a surface ...