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Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression
(Endocrine Society, 2005-05)
In previous studies of testicular biopsy tissue from healthy men,
intratesticular testosterone (ITT) has been shown to be much higher than
serum testosterone (T), suggesting that high ITT is needed relative to
serum T for normal spermatogenesis in men. However, the quantitative
relationship between ...
Male hormonal contraception: effects of injections of testosterone undecanoate and depot medroxyprogesterone acetate at eight-week intervals in chinese men
(Endocrine Society, 2004-05)
Surveys indicate that one form of acceptable male hormonal contraception
would consist of injections given at 2- to 3-month intervals. This report
describes a study of depot medroxyprogesterone acetate (DMPA) and
testosterone undecanoate (TU) injected at 8-wk intervals for suppression
of spermatogenesis ...
Impairment of Spermatogonial Development and Spermiation after Testosterone-Induced Gonadotropin Suppression in Adult Monkeys (Macaca fascicularis)
(The Endocrine Society, 2001-04)
Human male hormonal contraceptive regimens do not consistently induce
azoospermia, and the basis of this variable response is unclear. This
study used nine adult macaque monkeys (Macaca fascicularis) given
testosterone (T) implants for 20 weeks to study changes in germ cell
populations in relation ...
Immature spermatids are not prevalent in semen from men who are receiving androgen-based contraceptive regimens
(Elsevier, 1998-01)
OBJECTIVE: To determine whether immature spermatids increase in semen in
response to hormonal contraceptive treatments. Such a finding would
support the existence of a defect in spermiogenesis, which in turn may
explain the reported variability in sperm output. DESIGN: Semen smears
were obtained ...
Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone
(Endocrine Society, 2004-02)
Older men, particularly those with low serum testosterone (T) levels,
might benefit from T therapy to improve bone mineral density (BMD) and
reduce fracture risk. Concerns exist, however, about the impact of T
therapy on the prostate in older men. We hypothesized that the combination
of T and ...
Male hormonal contraception: suppression of spermatogenesis by injectable testosterone undecanoate alone or with levonorgestrel implants in chinese men
(American Society of Andrology, 2004-09)
Monthly injections of testosterone undecanoate (TU) act as a male
contraceptive by reversibly suppressing spermatogenesis to azoospermia or
severe oligoazoospermia in 95% of Chinese men. In 5% of Chinese men,
however, monthly TU administered alone fails to suppress spermatogenesis
into contraceptive ...
A clinical trial of injectable testosterone undecanoate as a potential male contraceptive in normal Chinese men
(Endocrine Society, 1999-10)
This is a pilot dose-finding study of spermatogenic suppression using
testosterone undecanoate (TU) injections alone in normal Chinese men.
Thirty-two healthy men were recruited. Volunteers underwent pretreatment
evaluation, then a treatment period in which group I (n = 13) received 500
mg TU, group ...
Quantitative (stereological) study of the normal spermatogenesis in the adult monkey (Macaca fascicularis)
(American Society of Andrology, 1997-11)
Germ cell and Sertoli cell numbers were estimated in six normal adult
monkeys (Macaca fascicularis) using a contemporary unbiased and efficient
stereological method--the optical disector. The data was used to assess
the efficiency of spermatogenesis from type B spermatogonia to elongated
spermatids. ...
Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T
(Endocrine Society, 2005-03)
Testosterone (T) therapy in older men with low serum T levels increases
lean body mass and decreases fat mass. These changes might improve
physical performance and strength; however, it has not been established
whether T therapy improves functional outcome in older men. Moreover,
concerns exist ...
Daily testosterone and gonadotropin levels are similar in azoospermic and nonazoospermic normal men administered weekly testosterone: implications for male contraceptive development
(American Society of Andrology, 2001-11)
Weekly intramuscular administration of testosterone esters such as
testosterone enanthate (TE) suppresses gonadotropins and spermatogenesis
and has been studied as a male contraceptive. For unknown reasons,
however, some men fail to achieve azoospermia with such regimens. We
hypothesized that either ...