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Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression
(Endocrine Society, 2005-05)
In previous studies of testicular biopsy tissue from healthy men,
intratesticular testosterone (ITT) has been shown to be much higher than
serum testosterone (T), suggesting that high ITT is needed relative to
serum T for normal spermatogenesis in men. However, the quantitative
relationship between ...
Male hormonal contraception: effects of injections of testosterone undecanoate and depot medroxyprogesterone acetate at eight-week intervals in chinese men
(Endocrine Society, 2004-05)
Surveys indicate that one form of acceptable male hormonal contraception
would consist of injections given at 2- to 3-month intervals. This report
describes a study of depot medroxyprogesterone acetate (DMPA) and
testosterone undecanoate (TU) injected at 8-wk intervals for suppression
of spermatogenesis ...
Impairment of Spermatogonial Development and Spermiation after Testosterone-Induced Gonadotropin Suppression in Adult Monkeys (Macaca fascicularis)
(The Endocrine Society, 2001-04)
Human male hormonal contraceptive regimens do not consistently induce
azoospermia, and the basis of this variable response is unclear. This
study used nine adult macaque monkeys (Macaca fascicularis) given
testosterone (T) implants for 20 weeks to study changes in germ cell
populations in relation ...
Immature spermatids are not prevalent in semen from men who are receiving androgen-based contraceptive regimens
(Elsevier, 1998-01)
OBJECTIVE: To determine whether immature spermatids increase in semen in
response to hormonal contraceptive treatments. Such a finding would
support the existence of a defect in spermiogenesis, which in turn may
explain the reported variability in sperm output. DESIGN: Semen smears
were obtained ...
Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone
(Endocrine Society, 2004-02)
Older men, particularly those with low serum testosterone (T) levels,
might benefit from T therapy to improve bone mineral density (BMD) and
reduce fracture risk. Concerns exist, however, about the impact of T
therapy on the prostate in older men. We hypothesized that the combination
of T and ...
A clinical trial of injectable testosterone undecanoate as a potential male contraceptive in normal Chinese men
(Endocrine Society, 1999-10)
This is a pilot dose-finding study of spermatogenic suppression using
testosterone undecanoate (TU) injections alone in normal Chinese men.
Thirty-two healthy men were recruited. Volunteers underwent pretreatment
evaluation, then a treatment period in which group I (n = 13) received 500
mg TU, group ...
Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T
(Endocrine Society, 2005-03)
Testosterone (T) therapy in older men with low serum T levels increases
lean body mass and decreases fat mass. These changes might improve
physical performance and strength; however, it has not been established
whether T therapy improves functional outcome in older men. Moreover,
concerns exist ...
The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: response to clomiphene citrate
(Endocrine Society, 1987-12)
Serum testosterone (T) levels in men decline with age while serum LH
levels, as measured by RIA, increase. To assess if the decline in serum T
levels in healthy aging men is paralleled by an age-related decline in the
bioavailable non-sex hormone-binding globulin (SHBG)-bound fraction of T
and to ...
Abnormal patterns of pulsatile luteinizing hormone in women with luteal phase deficiency
(Elsevier, 1984-05)
Luteal phase deficiency is usually a problem of inadequate progesterone
production associated with inadequate ovarian follicular development. The
hypothesis that luteal phase deficiency results from an abnormal secretion
pattern of luteinizing hormone (LH) was tested in these women. To this
end, ...
Decreased serum inhibin levels in normal elderly men: evidence for a decline in Sertoli cell function with aging
(Endocrine Society, 1988-09)
Compared to young men, normal elderly men have decreased sperm production
despite elevated serum gonadotropin levels. To determine whether the
seminiferous tubule defect in elderly men includes decreased Sertoli cell
function, we measured serum immunoreactive inhibin concentrations in young
and ...