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Reduction of dimensionality in a diffusion search process and kinetics of gene expression
(North-Holland (Elsevier), 2000-03-01)
In order to activate a gene in a DNA molecule a specific protein (transcription factor) has to bind to the promoter of the gene. We formulate and partially answer the following question: how much time does a transcription factor, which activates a given gene, need in order to find this gene inside the nucleus of a cell? The ...
Mechanisms for facilitated target location and the optimal number of molecules in the diffusion search process
(American Physical Society, 2001-06-26)
We investigate the number N of molecules needed to perform independent diffusions in order to achieve bonding of a single molecule to a specific site in time t [subscript] 0. For a certain range of values of t [subscript] 0, an increase from N to k · N molecules (k > 1) results in the decrease of search time from t [subscript] ...