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Prioritizing research: the use of risk prediction, value of information analyses, and portfolio evaluation to improve public investments in cancer clinical trials
Background: Fewer than half of all medical interventions in use today are supported by clinical evidence. Despite allocating more than $11 billion each year to support clinical research, federal funding for medical research lacks a coordinated system for prioritizing and allocating resources to efficiently address these ...
Effectiveness of home-based HIV testing and education among partners of pregnant women in Kenya: a mixed methods approach
Male partner involvement has been recognized as an important component of prevention-of-mother-to-child transmission of HIV (PMTCT); however, male antenatal attendance has been difficult to achieve. Home-based testing among pregnant couples may be an effective strategy to test men. Women attending their first antenatal visit ...
Fine Particle (PM2.5) Composition of Indoor and Outdoor Air Samples Collected in Xuanwei County, China
Indoor air pollution is a cause of many adverse health outcomes especially in developing countries where high levels of pollutants are generated by burning solid fuels for cooking and heating purposes. In China, the lung cancer rates are highest in Xuanwei County and the burning of coal in the home is thought to be a primary ...
The effect of armed conflict on maternal and child health services in Uganda, 2007-2010
The allocation and utilization of maternal and child health (MCH) services has been shown to be severely diminished during periods of protracted conflict. A limited body of research describes the lingering effects that civil war can have on already stressed health systems in sub-Saharan Africa. To assess the effects of conflict ...
A stakeholder analysis of the idea of a community-based obstetrical technician cadre in Haiti to replace aging traditional birth attendants
University of Washington Abstract A stakeholder analysis of the idea of a community-based obstetrical technician cadre in Haiti to replace aging traditional birth attendants Jean Marie David Rikerdy Frederic Chair of the Supervisory Committee: MD, MPH Scott Barnhart Stephen Gloyd Background Haiti has the highest maternal ...
Knowledge, attitudes and practices related to sexual and reproductive health among adolescents from two secondary schools in Chota, Cajamarca, Peru.
Adolescent pregnancy rates are increasing in Peru. Although the Ministry of Health collects data about adolescent pregnancies, little is known about the knowledge and practices of youth in rural areas to inform design of educational interventions. In 2014, 315 students in two secondary schools in the city of Chota, Cajamarca ...
Evaluation of data completeness of Client Intake Form (CIF) before and after Data Quality Audit (DQA) of a Voluntary Medical Male-Circumcision (VMMC) program in Zimbabwe
Abstract Purpose To evaluate and compare the data completeness of Client Intake Forms (CIFs) collected both before and after a Data Quality Audit (DQA) in February 2015 and to identify the factors contributing to incompleteness of CIFs used for the Voluntary Medical Male Circumcision (VMMC) procedure in Zimbabwe. Methods Four ...
Assessing the Clinical Management of Malaria in Under Five Children in Uganda: Exploring the Association Between Facility and Population-Based Data
Introduction: The Integrated Infectious Disease Capacity Building Evaluation (IDCAP) team evaluated two malaria case management interventions that were implemented in 36 health facilities in Uganda using facility-based and population-based data. The population survey was administered in the catchment areas surrounding the ...
The Return of Genetic Research Results in the Context of an International Colon Cancer Family Registry
The overall aim of this dissertation study was to describe the experience of the Colon Cancer Family Registry (C-CFR) with return of results (ROR) from genetic research and to document site-specific ROR outcomes. The C-CFR is comprised of six registry sites: the University of Hawaii, Honolulu, HI (HI); the Mayo Clinic, ...
Cost-utility analysis of EML4-ALK fusion testing followed by treatment with crizotinib in patients with Non-Small Cell Lung Cancer (NSCLC)
Objective NSCLC is the most common type of lung cancer and accounts for about 85% of all lung cancers. Currently a majority of patients with NSCLC are treated with surgical resection and/or cytotoxic drugs. Chemotherapy has resulted in a modest increase (median survival of 8 months with chemotherapy vs median survival of 5.7 ...