Now showing items 31-40 of 135
Serum inhibin levels during the periovulatory interval in normal women: relationships with sex steroid and gonadotrophin levels
(Blackwell Publishing, 1990-01)
Inhibin is a gonadal glycoprotein believed to be important in the regulation of pituitary FSH secretion and/or to function as a paracrine factor within the ovary and testis. We studied serum levels of inhibin, oestradiol (E2), progesterone (P), FSH and LH during the periovulatory interval in order ...
Gonadotropin-releasing hormone antagonist plus testosterone: a potential male contraceptive
(Endocrine Society, 1991-09)
No effective hormonal contraceptive has yet been devised for men. Through their suppressive effect on gonadotropin secretion, GnRH antagonists inhibit both testosterone (T) production and spermatogenesis in animals. Long term administration of an antagonist alone would result in androgen deficiency; ...
Nocturnal slowing of pulsatile luteinizing hormone secretion in women during the follicular phase of the menstrual cycle
(Endocrine Society, 1985-07)
The gonadotropin secretion pattern in normal reproductive age women (n = 5) was evaluated for the presence of a circadian rhythm. The women volunteered for a series of 24-h admissions in different phases of their menstrual cycles (early follicular, late follicular, and midluteal). Plasma LH and FSH ...
Endocrine correlates of sexual development in the male monkey, Macaca fascicularis
(Endocrine Society, 1981-09)
No abstract or description.
Intramuscular testosterone enanthate plus very low dosage oral levonorgestrel suppresses spermatogenesis without causing weight gain in normal young men: a randomized clinical trial
(American Society of Andrology, 2005-05)
The development of a safe, well-tolerated, effective, and reversible male hormonal contraceptive would be a major clinical advance for couples planning their family size and for control of population growth. High-dosage parenteral testosterone (T) esters alone or in combination with a progestogen ...
A single dose of the potent gonadotropin-releasing hormone antagonist acyline suppresses gonadotropins and testosterone for 2 weeks in healthy young men
(Endocrine Society, 2004-12)
Acyline is a novel GnRH antagonist that reliably inhibits gonadotropins and testosterone (T) levels in men for 48 h after a single dose up to 75 microg/kg. In this study we examined gonadotropin and T levels in 28 healthy young men administered acyline as single doses of 150 or 300 microg/kg or serial injections of 75 microg/kg. ...
Regulation of testicular function in men: implications for male hormonal contraceptive development
In the adult male, the testes produce both sperm and testosterone. The function of the testicles is directed by the central nervous system and pituitary gland. Precise regulation of testicular function is conferred by an elegant feedback loop in which the secretion of pituitary gonadotropins is ...
Testosterone-induced suppression of lipoprotein(a) in normal men; relation to basal lipoprotein(a) level
The concentration of lipoprotein(a) [Lp(a)] in human plasma is largely genetically determined and is inversely correlated to the size of apolipoprotein(a) [apo(a)]. Additionally, Lp(a) values are relatively stable within individuals and are only marginally susceptible to therapeutic treatment. The ...
Follicle-stimulating hormone is required for quantitatively normal inhibin secretion in men
(Endocrine Society, 1988-12)
Inhibin is a glycoprotein hormone produced by the testis and ovary which is postulated to be an important regulator of pituitary FSH secretion. Animal data indicate that inhibin is produced by the Sertoli cells of the testis under the influence of FSH. To determine the role of FSH withdrawal and ...
Single-dose administration of the gonadotropin-releasing hormone antagonist, Nal-Lys (antide) to healthy men
OBJECTIVE: To evaluate the ability the Nal-Lys GnRH antagonist ([N-Ac-Nal (2)1, 4ClDPhe2, D3Pal3, Lys (Nic)5, D-Lys(Nic)6, Lys (iPr)8, D-Ala10] to suppress gonadotropins and T in humans and to assess its duration of action and its local effects. DESIGN: Placebo-controlled clinical study. SETTING: ...