In order to activate a gene in a DNA molecule a specific protein (transcription factor) has to bind to the promoter of the gene. We formulate and partially answer the following question: how much time does a transcription factor, which activates a given gene, need in order to find this gene inside the nucleus of a cell? The ...

We present a simulation algorithm for a diffusion on a curved surface given by the equation [omega](r)50. The algorithm is tested against analytical results known for diffusion on a cylinder and a sphere, and applied to the diffusion on the P, D, and G periodic nodal surfaces. It should find application in an interpretation ...

We investigate the number N of molecules needed to perform independent diffusions in order to achieve bonding of a single molecule to a specific site in time t [subscript] 0. For a certain range of values of t [subscript] 0, an increase from N to k · N molecules (k > 1) results in the decrease of search time from t [subscript] ...

We study two-dimensional Brownian motion in an ordered periodic system of linear reflecting barriers using the sampling method and conformal transformations. We calculate the effective diffusivity for the Brownian particle. When the periods are fixed but the length of the barrier goes to zero, the effective diffusivity in ...