Browsing Department of Biostatistics Faculty Papers by Title
Now showing items 2-14 of 14
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A coarsened multinomial regression model for perinatal mother to child transmission of HIV
(2008)Background: In trials designed to estimate rates of perinatal mother to child transmission of HIV, HIV assays are scheduled at multiple points in time. Still, infection status for some infants at some time points may be ... -
The effect of different public health interventions on longevity, morbidity, and years of healthy life
(2007)Background: Choosing cost-effective strategies for improving the health of the public is difficult because the relative effects of different types of interventions are not well understood. The benefits of one-shot interventions ... -
Evaluation of methods for oligonucleotide array data via quantitative real-time PCR
(2006)Background: There are currently many different methods for processing and summarizing probelevel data from Affymetrix oligonucleotide arrays. It is of great interest to validate these methods and identify those that are ... -
Exon and junction microarrays detect widespread mouse strain- and sex-bias expression differences
(2008)Background: Studies have shown that genetic and sex differences strongly influence gene expression in mice. Given the diversity and complexity of transcripts produced by alternative splicing, we sought to use microarrays ... -
Male circumcision, religion, and infectious diseases: an ecologic analysis of 118 developing countries
(2006)Background: Both religious practices and male circumcision (MC) have been associated with HIV and other sexually-transmitted infectious diseases. Most studies have been limited in size and have not adequately controlled ... -
Managed care and patient ratings of the quality of specialty care among patients with pain or depressive symptoms
(2007)Background: Managed care efforts to regulate access to specialists and reduce costs may lower quality of care. Few studies have examined whether managed care is associated with patient perceptions of the quality of care ... -
Missing Confounding Data in Marginal Structural Models: A Comparison of Inverse Probability Weighting and Multiple Imputation
(2008)Standard statistical analyses of observational data often exclude valuable information from individuals with incomplete measurements. This may lead to biased estimates of the treatment effect and loss of precision. The ... -
Mortality ascertainment of participants in the National Wilms Tumor Study using the National Death Index: comparison of active and passive follow-up results
(2007)Long term studies of childhood cancer survivors are hampered by difficulties in tracking young adult participants. After performing a National Death Index (NDI) search we sought to identify which factors best predicted a ... -
A prospective cohort study of surgical treatment for back pain with degenerated discs; study protocol
(2005)Background: The diagnosis of discogenic back pain often leads to spinal fusion surgery and may partly explain the recent rapid increase in lumbar fusion operations in the United States. Little is known about how patients ... -
Synchrony of change in depressive symptoms, health status, and quality of life in persons with clinical depression
(2006)Background: Little is known about longitudinal associations among measures of depression, mental and physical health, and quality of life (QOL). We followed 982 clinically depressed persons to determine which measures ... -
Towards standardized measurement of adverse events in spine surgery: conceptual model and pilot evaluation
(2006)Background: Independent of efficacy, information on safety of surgical procedures is essential for informed choices. We seek to develop standardized methodology for describing the safety of spinal operations and apply these ... -
Transformations for cDNA Microarray Data
(2003)Two channel microarray data often contain systematic variations that can be minimized by data transformation prior to further analysis. The most commonly observed effects are revealed by viewing scatter plots of the logarithm ... -
Weight-modification trials in older adults: what should the outcome measure be?
(2002)Background: Overweight older adults are often counseled to lose weight, even though there is little evidence of excess mortality in that age group. Overweight and underweight may be more associated with health status than ...