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Immunization with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients

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dc.contributor.author Knutson, Keith L. en_US
dc.contributor.author Schiffman, Kathy en_US
dc.contributor.author Disis, Mary L. en_US
dc.date.accessioned 2010-03-31T18:47:12Z
dc.date.available 2010-03-31T18:47:12Z
dc.date.issued 2001-02-15 en_US
dc.identifier.citation Knutson KL, Schiffman K, Disis ML. Immunization with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients. J Clin Invest. 2001;107(4):477-484. en_US
dc.identifier.other 10.1172/JCI11752 en_US
dc.identifier.uri http://www.jci.org/articles/view/11752 en_US
dc.identifier.uri http://hdl.handle.net/1773/15594
dc.description.abstract CD4 T-cell help is required during the generation and maintenance of effective antitumor CD8 T cell–mediated immunity. The goal of this study was to determine whether HER-2/neu–specific CD8 T-cell immunity could be elicited using HER-2/neu–derived MHC class II “helper” peptides, which contain encompassed HLA-A2–binding motifs. Nineteen HLA-A2 patients with HER-2/neu–overexpressing cancers received a vaccine preparation consisting of putative HER-2/neu helper peptides p369–384, p688–703, and p971–984. Contained within these sequences are the HLA-A2–binding motifs p369–377, p689–697, and p971–979. After vaccination, the mean peptide-specific T-cell precursor frequency to the HLA-A2 peptides increased in the majority of patients. In addition, the peptide-specific T cells were able to lyse tumors. The responses were long-lived and detectable for more than 1 year after the final vaccination in select patients. These results demonstrate that HER-2/neu MHC class II epitopes containing encompassed MHC class I epitopes are able to induce long-lasting HER-2–specific IFN-γ–producing CD8 T cells. en_US
dc.description.sponsorship Department of Defense Breast Cancer Program (Knutson). NIH grants, the National Cancer Institute (R01 CA75163), and the Department of Defense Breast Cancer Program (Dsis). NIH grant MO1-RR-00037. en_US
dc.language.iso en_US en_US
dc.title Immunization with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients en_US


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