Browsing Research in Reproduction and Contraception, Center for by Title
Now showing items 201-220 of 220
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Suppression of plasma gonadotropins and testosterone in adult male monkeys (Macaca fascicularis) by a potent inhibitory analog of gonadotropin-releasing hormone
(Endocrine Society, 1986-01)The reduction of circulating levels of gonadotropins and testosterone is of value for the treatment of steroid-dependent neoplasms and the control of fertility. We tested the ability of single and multiple ... -
Suppression of spermatogenesis in man induced by Nal-Glu gonadotropin releasing hormone antagonist and testosterone enanthate (TE) is maintained by TE alone
(Endocrine Society, 1998-10)GnRH antagonists plus testosterone (T) suppress LH and FSH levels and inhibit spermatogenesis to azoospermia or severe oligozoospermia. High-dose T treatment alone has been shown to be an effective male ... -
Temporal control of protein synthesis during spermatogenesis
(Blackwell Publishing, 2000)During oogenesis and spermatogenesis transcription ceases prior to the differentiation of the mature cells. To complete germ cell differentiation and initiate early embryogenesis, proteins are synthesized ... -
A testis cytoplasmic RNA-binding protein that has the properties of a translational repressor
(American Society for Microbiology, 1996-06)Translation of the mouse protamine 1 (Prm-1) mRNA is repressed for several days during male germ cell differentiation. With the hope of cloning genes that regulate the translational repression of Prm-1, we ... -
Testosterone administration inhibits gonadotropin secretion by an effect directly on the human pituitary
(Endocrine Society, 1989-02)Testosterone (T) administration slows LH pulse frequency in man, presumably by an effect on the hypothalamic GnRH pulse generator, but it also may have a direct action on the pituitary. To determine if T ... -
Testosterone administration suppresses adiponectin levels in men
(American Society of Andrology, 2005-01)Testosterone (T) administration to men increases lean body mass and decreases fat mass. Adiponectin is produced by adipocytes and is thought to influence insulin sensitivity. In this study, we sought to ... -
Testosterone delivery using glutamide-based complex high axial ratio microstructures
(Elsevier, 2001-11)Complex high axial ratio microstructures (CHARMs) were evaluated for delivery of testosterone in vivo. Methods to incorporate testosterone included noncovalent mixing and covalent attachment of testosterone ... -
Testosterone enanthate at a dose of 200 mg/week decreases HDL-cholesterol levels in healthy men
(Blackwell Publishing, 1995-10)The concept that androgen alone can provide an effective male contraceptive has been tested in a multicentre, multiphase trial by the World Health Organization. Results from this trial showed that an ester ... -
Testosterone regulates pro-opiomelanocortin gene expression in the primate brain
(Endocrine Society, 1991-04)Endogenous opioid peptides such as beta-endorphin, derived from proopiomelanocortin (POMC), have been widely implicated as serving an important role in the neuroendocrine regulation of the primate ... -
Testosterone replacement in hypogonadal men: effects on obstructive sleep apnoea, respiratory drives, and sleep
(Blackwell Publishing, 1985-06)The obstructive sleep apnoea syndrome occurs predominantly in men. To determine the effect of testosterone on ventilatory function and whether testosterone may play a role in the development of obstructive ... -
Testosterone undecanoate maintains spermatogenic suppression induced by cyproterone acetate plus testosterone undecanoate in normal men
(Endocrine Society, 2003-12)In this study we evaluated whether testosterone undecanoate (TU), alone or combined with low dose cyproterone acetate (CPA), can maintain spermatogenic suppression induced by higher doses of CPA plus TU. ... -
Testosterone-induced suppression of lipoprotein(a) in normal men; relation to basal lipoprotein(a) level
(Elsevier, 1996-04-26)The concentration of lipoprotein(a) [Lp(a)] in human plasma is largely genetically determined and is inversely correlated to the size of apolipoprotein(a) [apo(a)]. Additionally, Lp(a) values are relatively ... -
Translational repression by MSY4 inhibits spermatid differentiation in mice
(Company Of Biologists Limited, 2002-08)In developing male germ cells, newly synthesized protamine mRNAs are stored for up to 7 days before translational activation. Translational repression of protamine 1 (Prm1) mRNA requires sequences present in ... -
Treatment of stage D2 prostatic carcinoma with combined gonadal and adrenal suppression in a 60-year-old man
(Elsevier, 1987-08)A 60-year-old man with stage D2 prostatic carcinoma received treatment with a new luteinizing hormone-releasing hormone superagonist. After a seven-month remission; relapse of the disease occurred and an ... -
Twenty-one day administration of dienogest reversibly suppresses gonadotropins and testosterone in normal men
(Endocrine Society, 2002-05)Androgen-progestin combinations are promising male contraceptive regimens. Optimization of these regimens includes the development of new progestins with more favorable biological properties. In this context ... -
Ultradian luteinizing hormone and testosterone rhythms in the adult male monkey, Macaca fascicularis
(Endocrine Society, 1980-11) -
Variability in sperm suppression during testosterone administration to adult monkeys is related to follicle stimulating hormone suppression and not to intratesticular androgens
(Endocrine Society, 2002-07)Sex steroid-based male contraceptive regimens do not induce consistent azoospermia. The reason for this variable response is obscure. We used normal adult male monkeys, Macaca fascicularis (n = 9) as a model of testosterone ... -
Variability of serum prolactin and progesterone levels in normal women: the relevance of single hormone measurements in the clinical setting
(Elsevier, 1990-07)In order to delineate factors contributing to variation in hormone levels, progesterone and prolactin (PRL) levels from 28 normal women, obtained daily during one menstrual cycle and every 20 minutes during ... -
What can spermatogonial transplants teach us about male reproductive biology?
(Endocrine Society, 2000-03)