Browsing Research in Reproduction and Contraception, Center for by Title
Now showing items 134-153 of 220
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Obesity and endocrine dysfunction in mice with deletions of both neuropeptide Y and galanin
(American Society for Microbiology, 2004-04)Neuropeptide Y (NPY) and galanin have both been implicated in the regulation of body weight, yet mice bearing deletions of either of these molecules have unremarkable metabolic phenotypes. To investigate ... -
Obstructive sleep apnea syndrome induced by testosterone administration
(Massachusetts Medical Society, 1983-03-03) -
Onset and characteristics of the midcycle surge in bioactive and immunoactive luteinizing hormone secretion in normal women: influence of physiological variations in periovulatory ovarian steroid hormone secretion
(Endocrine Society, 1992-08)Limited studies in nonhuman primates suggest that the midcycle LH surge is characterized by distinctly different patterns of bioactive (LH-BIO) and immunoactive (LH-RIA) LH secretion. To further examine the ... -
An oral regimen of cyproterone acetate and testosterone undecanoate for spermatogenic suppression in men
(Elsevier, 1997-11)OBJECTIVE: To test the effectiveness, safety, and reversibility of the combined administration of cyproterone acetate and T undecanoate. DESIGN: Open clinical trial. SETTING: Healthy volunteers in an academic ... -
Oral testosterone in oil plus dutasteride in men: a pharmacokinetic study
(Endocrine Society, 2005-05)Testosterone (T) is not administered orally, because it has been reported to be rapidly metabolized by the liver. We hypothesized that sufficient doses of T or T enanthate (TE), administered orally in oil, would result in ... -
Oral testosterone-triglyceride conjugate in rabbits: single-dose pharmacokinetics and comparison with oral testosterone undecanoate
(American Society of Andrology, 2003-09)Development of a safe and effective oral form of testosterone has been inhibited by the rapid hepatic metabolism of nonalkylated androgens. Since triglycerides are absorbed via lymphatics and bypass the liver, ... -
Ovarian follicular concentrations of activin, follistatin, inhibin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-2 (IGFBP-2), IGFBP-3, and vascular endothelial growth factor in spontaneous menstrual cycles of normal women of advanced reproductive age
(Endocrine Society, 2000-12)Previous studies indicate that the menstrual cycles of older reproductive age women are characterized by a selective elevation of FSH associated with early development and ovulation of a dominant follicle. ... -
Ovulation induction with pulsatile gonadotropin-releasing hormone: a study of the subcutaneous route of administration
(Elsevier, 1986-10)The efficacy of ovulation induction with the use of intermittent gonadotropin-releasing hormone (GnRH) therapy was examined in seven infertile women with hypothalamic amenorrhea. GnRH was administered every ... -
Packaging paternal chromosomes with protamine [comment]
(Nature Publishing Group, 2001-05) -
A pharmacokinetic study of injectable testosterone undecanoate in hypogonadal men
(American Society of Andrology, 1998-11)Testosterone undecanoate (TU) provides testosterone (T) replacement for hypogonadal men when administered orally but requires multiple doses per day and produces widely variable serum T levels. We investigated ... -
Phenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2)
(American Society for Microbiology, 2005-06)Galanin is a neuropeptide implicated in the regulation of feeding, reproduction, cognition, nociception, and seizure susceptibility. There are three known galanin receptor (GALR) subtypes (GALR1, GALR2, and ... -
Physiological levels of estradiol stimulate plasma high density lipoprotein2 cholesterol levels in normal men
(Endocrine Society, 1994-04)Premenopausal women have a lower risk of coronary artery disease than men or postmenopausal women; estrogens are thought to contribute to this lower risk. Administration of exogenous estrogen to post-menopausal ... -
The physiological significance of pulsatile LHRH secretion in man: gonadotrophin responses to physiological doses of pulsatile versus continuous LHRH administration
(Blackwell Publishing, 1991-02)This study tested whether pulsatile LHRH stimulation of the pituitary is required for normal gonadotrophin secretion in man. Four men with idiopathic hypogonadotrophic hypogonadism (IHH) and presumed endogenous ... -
Pituitary autonomy in hyperprolactinemic secondary amenorrhea: results of hypothalamic-pituitary testing
(Endocrine Society, 1977-05)Twenty-seven women with secondary amenorrhea of greater than six months duration were subjected to multiple testing of hypothalamo-pituitary function. They were divided into normo-prolactinemic (Group 1 mean ... -
Pituitary-thyroid responses to 4-hour constant infusions of thyrotropin releasing hormone in man
(Endocrine Society, 1977-11) -
Plzf is required in adult male germ cells for stem cell self-renewal
(Nature Publishing Group, 2004-06)Adult germline stem cells are capable of self-renewal, tissue regeneration and production of large numbers of differentiated progeny. We show here that the classical mouse mutant luxoid affects adult germline ... -
Post-transcriptional control of gene expression during spermatogenesis
(Elsevier, 1998-08)The synthesis and storage of mRNAs prior to their translation is a necessity during spermatogenesis as global transcription ceases several days prior to the completion of spermatid differentiation. ... -
Preoperative supraphysiological testosterone in older men undergoing knee replacement surgery
(Blackwell Publishing, 2002-10)OBJECTIVES: Older patients undergoing knee replacement surgery can recover more slowly than younger patients and require extended rehabilitation. Because administration of supraphysiological testosterone (T) ... -
Preservation of fertility despite subnormal gonadotropin and testosterone levels after cessation of pulsatile gonadotropin-releasing hormone therapy in a man with Kallmann's syndrome
(Elsevier, 1994-02)A man with IHH and anosmia presented in 1980. He was successfully treated with various hormonal regimens; four children were conceived with hCG or pulsatile GnRH therapy. The patient discontinued GnRH after ... -
Progesterone modulation of pulsatile luteinizing hormone secretion in normal women
(Endocrine Society, 1984-02)Recent studies show that the frequency and amplitude of pulsatile LH secretion change during the normal human menstrual cycle; however, the neuroendocrine mechanisms underlying these changes are poorly ...