Browsing Research in Reproduction and Contraception, Center for by Author "Cunningham, Matthew J."
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Cloning and distribution of galanin-like peptide mRNA in the hypothalamus and pituitary of the macaque
Steiner, Robert A.; Cunningham, Matthew J.; Scarlett, Jarrad M. (Endocrine Society, 2002-03)Galanin-like peptide (GALP) is a newly discovered hypothalamic neuropeptide, which is regulated by leptin and implicated in the regulation of GnRH secretion in the rodent. We searched the human genome ... -
Distribution and regulation of galanin-like peptide (GALP) in the hypothalamus of the mouse
Johnson, Laura L.; Clifton, Donald K.; Li, Dorothy; Steiner, Robert A.; Teklemichael, Dawit N.; Krasnow, Stephanie M.; Jureus, Anders; Cunningham, Matthew J. (Endocrine Society, 2001-12)Galanin-like peptide (GALP) is a newly discovered molecule whose expression in the brain is confined to the arcuate nucleus and median eminence. In the rat, cellular levels of GALP mRNA are reduced by fasting ... -
Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat
Clifton, Donald K.; McClain, Molly E.; Steiner, Robert A.; Jureus, Anders; Cunningham, Matthew J. (Endocrine Society, 2000-07)Galanin-like peptide (GALP), which was recently isolated from the porcine hypothalamus, shares sequence homology with galanin and binds with high affinity to galanin receptors. To study the distribution and ... -
Galanin-like peptide as a possible link between metabolism and reproduction in the macaque
Scarlett, Jarrad M.; Smith, M. Susan; Grove, Kevin L.; Clifton, Donald K.; Cameron, Judy L.; Plant, Tony M.; Steiner, Robert A.; Cunningham, Matthew J.; Shahab, Muhammad (Endocrine Society, 2004-04)Galanin-like peptide (GALP) is a hypothalamic neuropeptide that has been implicated in the control of feeding, metabolism, and reproduction. The goal of this study was to examine the effects of central infusions ... -
Regulation of Kiss1 gene expression in the brain of the female mouse
Smith, Jeremy T.; Steiner, Robert A.; Cunningham, Matthew J.; Clifton, Donald K.; Rissman, Emilie F. (Endocrine Society, 2005-09)The Kiss1 gene encodes a family of neuropeptides called kisspeptins, which activate the receptor G protein-coupled receptor-54 and play a role in the neuroendocrine regulation of GnRH secretion. We examined ... -
A role for kisspeptins in the regulation of gonadotropin secretion in the mouse
Clifton, Donald K.; Steiner, Robert A.; Smith, Jeremy T.; Gottsch, Michelle L.; Crowley, W. F.; Acohido, B. V.; Cunningham, Matthew J.; Popa, Simina M.; Seminara, S. (Endocrine Society, 2004-09)Kisspeptins are products of the KiSS-1 gene, which bind to a G protein-coupled receptor known as GPR54. Mutations or targeted disruptions in the GPR54 gene cause hypogonadotropic hypogonadism in humans and ... -
Serotonergic neurons are targets for leptin in the monkey
Clifton, Donald K.; Rickard, Diana G.; Steiner, Robert A.; Finn, Patricia D.; Cunningham, Matthew J. (Endocrine Society, 2001-01)Leptin is a secretory product of adipocytes that has been shown to affect food intake, metabolism, and reproduction. One site of leptin's action is the central nervous system, where the leptin receptor (Ob-R) ...