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Browsing Research in Reproduction and Contraception, Center for by Subject "Adult"
Now showing items 1-20 of 103
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Abnormal patterns of pulsatile luteinizing hormone in women with luteal phase deficiency
(Elsevier, 1984-05)Luteal phase deficiency is usually a problem of inadequate progesterone production associated with inadequate ovarian follicular development. The hypothesis that luteal phase deficiency results from an abnormal ... -
Acyline: the first study in humans of a potent, new gonadotropin-releasing hormone antagonist
(Endocrine Society, 2002-07)Acyline is a novel GnRH antagonist found in animal studies to be a potent suppressor of circulating gonadotropin and testosterone (T) levels. We conducted the first study of acyline administration to humans. ... -
Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study
(Endocrine Society, 2002-02)We used longitudinal data from the Massachusetts Male Aging Study, a large population-based random-sample cohort of men aged 40-70 yr at baseline, to establish normative age trends for serum level of T and ... -
Age-related analysis of inhibin A, inhibin B, and activin a relative to the intercycle monotropic follicle-stimulating hormone rise in normal ovulatory women
(Endocrine Society, 2004-06)Previous studies have reported that the monotropic rise in FSH in older women is associated with decreased inhibin B and/or A levels and increased levels of activin A. Whereas most investigators have found ... -
Annual patterns of luteinizing hormone, follicle stimulating hormone, testosterone and inhibin in normal men
(Oxford University Press, 1996-02)Reproductive functions in most animals demonstrate seasonal fluctuations that allow young to be born at a time of the year favourable for their survival. Whether there is a seasonal change in the human ... -
The anterior pituitary response to a gonadotropin-releasing hormone challenge test in normal older reproductive-age women
(Elsevier, 1996-03)OBJECTIVE: To assess the pituitary responsiveness to GnRH stimulation of premenopausal women relative to age. DESIGN: Older and younger reproductive-age women underwent the GnRH stimulation test in the early ... -
The association of D-group chromosomal translocations and defective spermatogenesis
(Elsevier, 1976-02)D-group chromosome translocations have been associated in isolated cases with infertility in males. In this study, we demonstrated the effect of a translocated D-group chromosome on spermatogenesis as it had ... -
Bone mineral content of amenorrheic and eumenorrheic athletes
(Massachusetts Medical Society, 1984-08-02)This study was designed to determine whether the hypoestrogenic status of 14 amenorrheic athletes was associated with a decrease in regional bone mass relative to that of 14 of their eumenorrheic peers. The ... -
Chronic human chorionic gonadotropin administration in normal men: evidence that follicle-stimulating hormone is necessary for the maintenance of quantitatively normal spermatogenesis in man
(Endocrine Society, 1986-06)The role of FSH in the maintenance of spermatogenesis in man is poorly understood. To determine whether normal serum levels of FSH are necessary for the maintenance of quantitatively normal spermatogenesis, ... -
Circadian variation in testosterone, sex hormone-binding globulin, and calculated non-sex hormone-binding globulin bound testosterone in healthy young and elderly men
(American Society of Andrology, 1989-09)The circadian pattern in levels of serum total testosterone (T) in men becomes blunted with normal aging. However, because T not bound to sex hormone-binding globulin (non-SHBG-T) is felt to be a better ... -
A clinical trial of injectable testosterone undecanoate as a potential male contraceptive in normal Chinese men
(Endocrine Society, 1999-10)This is a pilot dose-finding study of spermatogenic suppression using testosterone undecanoate (TU) injections alone in normal Chinese men. Thirty-two healthy men were recruited. Volunteers underwent ... -
Cognitive effects of short-term manipulation of serum sex steroids in healthy young men
(Endocrine Society, 2002-07)We examined the effects of sex steroids on cognitive functioning by exogenously manipulating circulating T levels in a group of healthy young men. Thirty-two men were randomized to receive 8 wk of treatment ... -
Colchicine and testicular function in man
(Massachusetts Medical Society, 1976-06-17) -
Combined administration of levonorgestrel and testosterone induces more rapid and effective suppression of spermatogenesis than testosterone alone: a promising male contraceptive approach
(Endocrine Society, 1996-02)Studies using high dose testosterone (T) administration in normal men as a male contraceptive have resulted in azoospermia rates of only 50-70%. Previous studies of T and progestogen combinations have shown ... -
A combined regimen of cyproterone acetate and testosterone enanthate as a potentially highly effective male contraceptive
(Endocrine Society, 1996-08)In this study we tested the effectiveness of the combined administration of cyproterone acetate (CPA) and testosterone enanthate (TE) in suppressing spermatogenesis. After a control phase of 3 months, 15 ... -
Comparison of a gonadotropin releasing-hormone antagonist plus testosterone (T) versus T alone as potential male contraceptive regimens
(Endocrine Society, 1993-08)Efforts to develop a hormonal contraceptive regimen for men have focused on administration of testosterone (T), alone or together with other agents. Previous regimens have successfully induced azoospermia in ... -
A comparison of the suppressive effects of testosterone and a potent new gonadotropin-releasing hormone antagonist on gonadotropin and inhibin levels in normal men
(Endocrine Society, 1989-07)GnRH antagonists have been developed in large part because of their potential use as contraceptive agents, particularly in men. Specifically, it was hoped that GnRH antagonists combined with testosterone (T) ... -
Corpus luteum insufficiency induced by a rapid gonadotropin-releasing hormone-induced gonadotropin secretion pattern in the follicular phase
(Endocrine Society, 1987-09)The pulse frequency of LH and FSH (and by inference, GnRH) is a major determinant of the relative baseline plasma levels of LH and FSH. Luteal phase deficiency has been reported to be associated with increased ... -
The corpus luteum: determinants of progesterone secretion in the normal menstrual cycle
(Elsevier, 1988-05)Fourteen normal volunteers were studied during one menstrual cycle. Follicular development, the luteinizing hormone (LH) surge, and the relationship between LH and progesterone secretion in the luteal phase ... -
Daily testosterone and gonadotropin levels are similar in azoospermic and nonazoospermic normal men administered weekly testosterone: implications for male contraceptive development
(American Society of Andrology, 2001-11)Weekly intramuscular administration of testosterone esters such as testosterone enanthate (TE) suppresses gonadotropins and spermatogenesis and has been studied as a male contraceptive. For unknown reasons, ...