Now showing items 1-10 of 10

    • Activation of the sympathetic nervous system by galanin-like peptide--a possible link between leptin and metabolism 

      Fraley, Gregory S.; Steiner, Robert A.; Nolan, Michael A.; Clifton, Donald K.; Baumgartner, James W.; Hansen, Karl R.; Krasnow, Stephanie M. (Endocrine Society, 2003-11)
      The effects of leptin upon body weight (BW) cannot be explained by its anorectic actions alone. Part of the metabolic changes elicited by leptin includes sympathetic nervous system activation leading to ...
    • Distribution and regulation of galanin-like peptide (GALP) in the hypothalamus of the mouse 

      Johnson, Laura L.; Clifton, Donald K.; Li, Dorothy; Steiner, Robert A.; Teklemichael, Dawit N.; Krasnow, Stephanie M.; Jureus, Anders; Cunningham, Matthew J. (Endocrine Society, 2001-12)
      Galanin-like peptide (GALP) is a newly discovered molecule whose expression in the brain is confined to the arcuate nucleus and median eminence. In the rat, cellular levels of GALP mRNA are reduced by fasting ...
    • Effect of fasting, refeeding, and dietary fat restriction on plasma leptin levels 

      Steiner, Robert A.; Connor, William E.; Kuijper, Joseph L.; Soules, Michael R.; Weigle, David S.; Duell, P. Barton (Endocrine Society, 1997-02)
      The factors responsible for the variability in plasma leptin levels observed among individuals with similar body compositions remain unclear. To examine the impact of dietary variables, we compared the changes ...
    • Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat 

      Clifton, Donald K.; McClain, Molly E.; Steiner, Robert A.; Jureus, Anders; Cunningham, Matthew J. (Endocrine Society, 2000-07)
      Galanin-like peptide (GALP), which was recently isolated from the porcine hypothalamus, shares sequence homology with galanin and binds with high affinity to galanin receptors. To study the distribution and ...
    • Leptin is a metabolic gate for the onset of puberty in the female rat 

      Weigle, David S.; Kuijper, Joseph L.; Steiner, Robert A.; Clifton, Donald K.; Cheung, Clement C.; Thornton, Janice E. (Endocrine Society, 1997-02)
      The timing of puberty onset in mammals is tightly coupled to the animal's nutritional and metabolic state. We conducted two experiments to test the hypothesis that leptin acts as a metabolic signal for the ...
    • Leptin is a metabolic signal to the reproductive system 

      Ren, Hongping; Clifton, Donald K.; Weigle, David S.; Steiner, Robert A.; Kuijper, Joseph L.; Kabigting, Emilia B.; Barash, Ilona A.; Cheung, Clement C. (Endocrine Society, 1996-07)
      Leptin, a newly-discovered hormonal product of the obese (ob) gene, is expressed by adipocytes and thought to play a role in the regulation of food intake and metabolism. We tested the hypothesis that leptin ...
    • Lords and ladies leapin' on leptin [editorial; comment] 

      Steiner, Robert A. (Endocrine Society, 1996-11)
    • A role for galanin-like peptide in the integration of feeding, body weight regulation, and reproduction in the mouse 

      Baumgartner, James W.; Schuh, Sonya M.; Steiner, Robert A.; Clifton, Donald K.; Krasnow, Stephanie M.; Fraley, Gregory S. (Endocrine Society, 2003-03)
      Galanin-like peptide (GALP) shares sequence homology with galanin and binds to galanin receptors in vitro. GALP neurons in the arcuate nucleus coexpress leptin receptors, and GALP mRNA expression is up-regulated ...
    • Serotonergic neurons are targets for leptin in the monkey 

      Clifton, Donald K.; Rickard, Diana G.; Steiner, Robert A.; Finn, Patricia D.; Cunningham, Matthew J. (Endocrine Society, 2001-01)
      Leptin is a secretory product of adipocytes that has been shown to affect food intake, metabolism, and reproduction. One site of leptin's action is the central nervous system, where the leptin receptor (Ob-R) ...
    • Testosterone administration suppresses adiponectin levels in men 

      Coviello, Andrea D.; Bremner, William J.; Amory, John K.; Matsumoto, Alvin M.; Anawalt, Bradley D.; Page, Stephanie T.; Herbst, Karen L. (American Society of Andrology, 2005-01)
      Testosterone (T) administration to men increases lean body mass and decreases fat mass. Adiponectin is produced by adipocytes and is thought to influence insulin sensitivity. In this study, we sought to ...