Now showing items 3-13 of 13

    • Evolutionary conservation of regulated longevity assurance mechanisms 

      McElwee, Joshua J.; Schuster, Eugene; Blanc, Eric; Piper, Matthew D.; Thomas, James H.; Patel, Dhaval S.; Selman, Colin; Withers, Dominic J.; Thorton, Janet M.; Partridge, Linda; Gems, David (2007)
      Background: To what extent are the determinants of aging in animal species universal? Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) is an evolutionarily conserved (public) regulator of longevity; yet it remains ...
    • The genomic distribution of intraspecific and interspecific sequence divergence of human segmental duplications relative to human/chimpanzee chromosomal rearrangements 

      Marques-Bonet, Tom�s; Cheng, Ze; She, Xinwei; Eichler, Evan E.; Navarro, Arcadi (2008)
      Background: It has been suggested that chromosomal rearrangements harbor the molecular footprint of the biological phenomena which they induce, in the form, for instance, of changes in the sequence divergence rates of ...
    • Hominoid chromosomal rearrangements on 17q map to complex regions of segmental duplication 

      Cardone, Maria Francesca; Jiang, Zhaoshi; D'Addabbo, Pietro; Archidiacono, Nicoletta; Rocchi, Mariano; She, Xinwei; Eichler, Evan E.; Ventura, Mario. (2008)
      Background: Chromosomal rearrangements, such as translocations and inversions, are recurrent phenomena during evolution, and both of them are involved in reproductive isolation and speciation. To better understand the ...
    • Independent centromere formation in a capricious, gene-free domain of chromosome 13q21 in Old World monkeys and pigs 

      Cardone, Maria Francesca; Alonso, Alicia; Pazienza, Michele; Ventura, Mario; Montermurro, Gabriella; Carbone, Lucia; De Jong, Pieter J.; Stanyon, Roscoe; D'Addabbo, Pietro; Archidiacono, Nicoletta; She, Xinwei; Eichler, Evan E.; Warburton, Peter E.; Rocchi, Mariano (2006)
      Background: Evolutionary centromere repositioning and human analphoid neocentromeres occurring in clinical cases are, very likely, two stages of the same phenomenon whose properties still remain substantially obscure. ...
    • Interaction of an atypical Plasmodium falciparum ETRAMP with human apolipoproteins 

      Vignali, Marissa; McKinlay, Anastasia; LaCount, Douglas J.; Chettier, Rakesh; Bell, Russell; Sahasrabudhe, Sudhir; Hughes, Robert E.; Fields, Stanley (2008)
      Background: In order to establish a successful infection in the human host, the malaria parasite Plasmodium falciparum must establish interactions with a variety of human proteins on the surface of different cell types, ...
    • Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase 

      Hawkins, Vivian N.; Auliff, Alyson; Prajapati, Surendra Kumar; Rungsihirunrat, Kanchana; Hapuarachchi, Hapuarachchige C.; Maestre, Amanda; O'Neil, Michael T.; Cheng, Qin; Joshi, Hema; Nabangchang, Kesara; Sibley, Carol Hopkins (2008)
      Background: In order to maximize the useful therapeutic life of antimalarial drugs, it is crucial to understand the mechanisms by which parasites resistant to antimalarial drugs are selected and spread in natural populations. ...
    • On the number of founding germ cells in humans 

      Zheng, Chang-Jiang; Luebeck, E. Georg; Byers, Breck E.; Moolgavkar, Suresh H. (2005)
      Background: The number of founding germ cells (FGCs) in mammals is of fundamental significance to the fidelity of gene transmission between generations, but estimates from various methods vary widely. In this paper we ...
    • The rationale and plan for creating a World Antimalarial Resistance Network (WARN) 

      Sibley, Carol Hopkins; Barnes, Karen I.; Plowe, Christopher V. (2007)
      Drug resistant malaria was a major factor contributing to the failure of a worldwide campaign to eradicate malaria in the last century, and now threatens the large investment being made by the global community in the rollout ...
    • World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility 

      Bacon, David J.; Jambou, Ronan; Fandeur, Thierry; Le Bras, Jacques; Wongsrichanalai, Chansuda; Fukuda, Mark M.; Ringwald, Pascal; Sibley, Carol Hopkins; Kyle, Dennis E. (2007)
      Intrinsic resistance of Plasmodium falciparum is clearly a major determinant of the clinical failure of antimalarial drugs. However, complex interactions between the host, the parasite and the drug obscure the ability to ...
    • World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria 

      Plowe, Christopher V.; Roper, Cally; Barnwell, John W.; Happi, Christian T.; Joshi, Hema H.; Mbacham, Wilfred; Meshnick, Steven R.; Mugittu, Kefas; Naidoo, Inbarani; Price, Ric N.; Shafer, Robert W.; Sibley, Carol Hopkins; Sutherland, Colin J.; Zimmerman, Peter A.; Rosenthal, Phillip J. (2007)
      Molecular markers for drug resistant malaria represent public health tools of great but mostly unrealized potential value. A key reason for the failure of molecular resistance markers to live up to their potential is that ...
    • World Antimalarial Resistance Network (WARN) IV: Clinical pharmacology 

      Barnes, Karen I.; Lindegardh, Niklas; Ogundahunsi, Olumide; Olliaro, Piero; Plowe, Christopher V.; Randrianarievelojosia, Milijaona; Gbotosho, Grace O.; Watkins, William M.; Sibley, Carol Hopkins; White, Nicholas J. (2007)
      A World Antimalarial Resistance Network (WARN) database has the potential to improve the treatment of malaria, through informing current drug selection and use and providing a prompt warning of when treatment policies need ...