Browsing Department of Genome Sciences Faculty Papers by Title
Now showing items 11-16 of 16
-
On the number of founding germ cells in humans
(2005)Background: The number of founding germ cells (FGCs) in mammals is of fundamental significance to the fidelity of gene transmission between generations, but estimates from various methods vary widely. In this paper we ... -
The rationale and plan for creating a World Antimalarial Resistance Network (WARN)
(2007)Drug resistant malaria was a major factor contributing to the failure of a worldwide campaign to eradicate malaria in the last century, and now threatens the large investment being made by the global community in the rollout ... -
Resolving multicopy duplications de novo using polyploid phasing
(Springer, 2017-05)While the rise of single-molecule sequencing systems has enabled an unprecedented rise in the ability to assemble complex regions of the genome, long segmental duplications in the genome still remain a challenging ... -
World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility
(2007)Intrinsic resistance of Plasmodium falciparum is clearly a major determinant of the clinical failure of antimalarial drugs. However, complex interactions between the host, the parasite and the drug obscure the ability to ... -
World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria
(2007)Molecular markers for drug resistant malaria represent public health tools of great but mostly unrealized potential value. A key reason for the failure of molecular resistance markers to live up to their potential is that ... -
World Antimalarial Resistance Network (WARN) IV: Clinical pharmacology
(2007)A World Antimalarial Resistance Network (WARN) database has the potential to improve the treatment of malaria, through informing current drug selection and use and providing a prompt warning of when treatment policies need ...