Now showing items 12-16 of 16

    • The rationale and plan for creating a World Antimalarial Resistance Network (WARN) 

      Sibley, Carol Hopkins; Barnes, Karen I.; Plowe, Christopher V. (2007)
      Drug resistant malaria was a major factor contributing to the failure of a worldwide campaign to eradicate malaria in the last century, and now threatens the large investment being made by the global community in the rollout ...
    • Resolving multicopy duplications de novo using polyploid phasing 

      Chaisson, Mark J; Mukherjee, Sudipto; Kannan, Sreeram; Eichler, Evan E (Springer, 2017-05)
      While the rise of single-molecule sequencing systems has enabled an unprecedented rise in the ability to assemble complex regions of the genome, long segmental duplications in the genome still remain a challenging ...
    • World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility 

      Bacon, David J.; Jambou, Ronan; Fandeur, Thierry; Le Bras, Jacques; Wongsrichanalai, Chansuda; Fukuda, Mark M.; Ringwald, Pascal; Sibley, Carol Hopkins; Kyle, Dennis E. (2007)
      Intrinsic resistance of Plasmodium falciparum is clearly a major determinant of the clinical failure of antimalarial drugs. However, complex interactions between the host, the parasite and the drug obscure the ability to ...
    • World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria 

      Plowe, Christopher V.; Roper, Cally; Barnwell, John W.; Happi, Christian T.; Joshi, Hema H.; Mbacham, Wilfred; Meshnick, Steven R.; Mugittu, Kefas; Naidoo, Inbarani; Price, Ric N.; Shafer, Robert W.; Sibley, Carol Hopkins; Sutherland, Colin J.; Zimmerman, Peter A.; Rosenthal, Phillip J. (2007)
      Molecular markers for drug resistant malaria represent public health tools of great but mostly unrealized potential value. A key reason for the failure of molecular resistance markers to live up to their potential is that ...
    • World Antimalarial Resistance Network (WARN) IV: Clinical pharmacology 

      Barnes, Karen I.; Lindegardh, Niklas; Ogundahunsi, Olumide; Olliaro, Piero; Plowe, Christopher V.; Randrianarievelojosia, Milijaona; Gbotosho, Grace O.; Watkins, William M.; Sibley, Carol Hopkins; White, Nicholas J. (2007)
      A World Antimalarial Resistance Network (WARN) database has the potential to improve the treatment of malaria, through informing current drug selection and use and providing a prompt warning of when treatment policies need ...