Now showing items 1-6 of 6

    • A database of antimalarial drug resistance 

      Sibley, Carol Hopkins; Ringwald, Pascal (2006)
      A large investment is required to develop, license and deploy a new antimalarial drug. Too often, that investment has been rapidly devalued by the selection of parasite populations resistant to the drug action. To understand ...
    • Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase 

      Hawkins, Vivian N.; Auliff, Alyson; Prajapati, Surendra Kumar; Rungsihirunrat, Kanchana; Hapuarachchi, Hapuarachchige C.; Maestre, Amanda; O'Neil, Michael T.; Cheng, Qin; Joshi, Hema; Nabangchang, Kesara; Sibley, Carol Hopkins (2008)
      Background: In order to maximize the useful therapeutic life of antimalarial drugs, it is crucial to understand the mechanisms by which parasites resistant to antimalarial drugs are selected and spread in natural populations. ...
    • The rationale and plan for creating a World Antimalarial Resistance Network (WARN) 

      Sibley, Carol Hopkins; Barnes, Karen I.; Plowe, Christopher V. (2007)
      Drug resistant malaria was a major factor contributing to the failure of a worldwide campaign to eradicate malaria in the last century, and now threatens the large investment being made by the global community in the rollout ...
    • World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility 

      Bacon, David J.; Jambou, Ronan; Fandeur, Thierry; Le Bras, Jacques; Wongsrichanalai, Chansuda; Fukuda, Mark M.; Ringwald, Pascal; Sibley, Carol Hopkins; Kyle, Dennis E. (2007)
      Intrinsic resistance of Plasmodium falciparum is clearly a major determinant of the clinical failure of antimalarial drugs. However, complex interactions between the host, the parasite and the drug obscure the ability to ...
    • World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria 

      Plowe, Christopher V.; Roper, Cally; Barnwell, John W.; Happi, Christian T.; Joshi, Hema H.; Mbacham, Wilfred; Meshnick, Steven R.; Mugittu, Kefas; Naidoo, Inbarani; Price, Ric N.; Shafer, Robert W.; Sibley, Carol Hopkins; Sutherland, Colin J.; Zimmerman, Peter A.; Rosenthal, Phillip J. (2007)
      Molecular markers for drug resistant malaria represent public health tools of great but mostly unrealized potential value. A key reason for the failure of molecular resistance markers to live up to their potential is that ...
    • World Antimalarial Resistance Network (WARN) IV: Clinical pharmacology 

      Barnes, Karen I.; Lindegardh, Niklas; Ogundahunsi, Olumide; Olliaro, Piero; Plowe, Christopher V.; Randrianarievelojosia, Milijaona; Gbotosho, Grace O.; Watkins, William M.; Sibley, Carol Hopkins; White, Nicholas J. (2007)
      A World Antimalarial Resistance Network (WARN) database has the potential to improve the treatment of malaria, through informing current drug selection and use and providing a prompt warning of when treatment policies need ...