• High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector 

  Zhang, Xiao-Bing; Beard, Brian C.; Trobridge, Grant D.; Wood, Brent L.; Sale, George E.; Sud, Reeteka; Humphries, Keith; Kiem, Hans-Peter (2008-03-20)

  Retroviral vector–mediated HSC gene therapy has been used to treat individuals with a number of life-threatening diseases. However, some patients with SCID-X1 developed retroviral vector–mediated leukemia after treatment. ...
• Toxicology evaluation of radiotracer doses of 3'-deoxy-3'-[18F]fluorothymidine (18F-FLT) for human PET imaging 

  Turcotte, Eric; Wiens, Linda W.; Grierson, John R.; Peterson, Lanell M.; Wener, Mark H.; Vesselle, Hubert (2007)

  Background: 18F-FLT is a novel PET radiotracer which has demonstrated a strong potential utility for imaging cellular proliferation in human tumors in vivo. To facilitate future regulatory approval of 18F-FLT for clinical ...
• Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection 

  Boriskin, Yury S.; P�cheur, Eve-Isabelle; Polyak, Stephen J. (2006)

  Arbidol (ARB) is an antiviral compound that was originally proven effective for treatment of influenza and several other respiratory viral infections. The broad spectrum of ARB anti-viral activity led us to evaluate its ...
• Cytogenetic characterization and H-ras associated transformation of immortalized human mammary epithelial cells 

  Rao, Krishna; Alper, Ozge; Opheim, Kent E.; Bonnet, George; Wolfe, Kristine; Larivee, Siobhan O'Hara; Porter, Peggy; McDougall, James K. (2006)

  Introduction: Immortalization is a key step in malignant transformation, but immortalization alone is insufficient for transformation. Human mammary epithelial cell (HMEC) transformation is a complex process that requires ...
• Use of "biokit HSV-2 Rapid Assay" to improve the positive predictive value of Focus HerpeSelect HSV-2 ELISA 

  Morrow, Rhoda Ashley; Friedrich, David; Meier, Amalia; Corey, Lawrence (2005)

  Background: Commercially available assays to detect antibodies to the herpes simplex virus type 2 (HSV-2)-specific glycoprotein gG-2 have markedly improved serologic diagnosis of HSV-2 infection. However, even tests with ...

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