Browsing Department of Laboratory Medicine Faculty Papers by Author "Beard, Brian C."

Now showing items 1-1 of 1

High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector

Zhang, Xiao-Bing; Beard, Brian C.; Trobridge, Grant D.; Wood, Brent L.; Sale, George E.; Sud, Reeteka; Humphries, Keith; Kiem, Hans-Peter (2008-03-20)

Retroviral vector–mediated HSC gene therapy has been used to treat individuals with a number of life-threatening diseases. However, some patients with SCID-X1 developed retroviral vector–mediated leukemia after treatment. ...