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Enzyme estimates of infarct size correlate with functional and clinical outcomes in the setting of ST-segment elevation myocardial infarction
(2005-08-23)
Background: Cardiac biomarkers are routinely obtained in the setting of suspected myocardial
ischemia and infarction. Evidence suggests these markers may correlate with functional and clinical
outcomes, but the strength of this correlation is unclear. The relationship between enzyme
measures of myocardial necrosis and left ...
Integrative analysis of RUNX1 downstream pathways and target genes
(2008)
Background: The RUNX1 transcription factor gene is frequently mutated in sporadic myeloid and lymphoid leukemia through translocation, point mutation or amplification. It is also responsible for
a familial platelet disorder with predisposition to acute myeloid leukemia (FPD-AML). The disruption of the largely unknown biological ...
Bacterial neuraminidase facilitates mucosal infection by participating in biofilm production
(2006-08-01)
Many respiratory pathogens, including Hemophilus influenzae, Streptococcus pneumoniae, and Pseudomonas aeruginosa, express neuraminidases that can cleave α2,3-linked sialic acids from glycoconjugates. As mucosal surfaces are heavily sialylated, neuraminidases have been thought to modify epithelial cells by exposing potential ...
Potential of essential fatty acid deficiency with extremely low fat diet in lipoprotein lipase deficiency during pregnancy: A case report
(2004)
Background: Pregnancy in patients with lipoprotein lipase deficiency is associated with high risk of maternal pancreatitis and fetal death. A very low fat diet (less than 10% of calories) is the primary treatment modality for the prevention of acute pancreatitis, a rare but potentially serious
complication of severe ...