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Browsing Laboratory Medicine and Pathology, Department of by Author "Prehn, Richmond T."
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Does the immune reaction cause malignant transformation by disrupting cell-to-cell or cell-to-matrix communications?
Prehn, Richmond T. (2007)Tumor progression: In many (perhaps in all) tumor systems, a malignant cancer is preceded by a benign lesion. Most benign lesions do not transform to malignancy and many regress. The final transformative step to malignancy ... -
An immune reaction may be necessary for cancer development
Prehn, Richmond T. (2006)Background: The hypothesis of immunosurveillance suggests that new neoplasms arise very frequently, but most are destroyed almost at their inception by an immune response. Its correctness has been debated for many years. ... -
Immunostimulation and Immunoinhibition of Premalignant Lesions
Prehn, Richmond T. (2007)Background: The immune reaction may be either stimulatory or inhibitory to tumor growth, depending upon the local ratio of immune reactants to tumor cells. Hypothesis: A tumor-stimulatory immune response may be essential ... -
The paradoxical effects of splenectomy on tumor growth
Prehn, Richmond T. (2006)Background: There is a vast and contradictory literature concerning the effect of the spleen and particularly of splenectomy on tumor growth. Sometimes splenectomy seems to inhibit tumor growth, but in other cases it seems, ... -
Prehn, R. On the nature of cancer and why anticancer vaccines don't work
Prehn, Richmond T. (2005)In this essay I suggest that the major difficulty in producing effective anti-cancer vaccines lies in the fact that most cancers have little immunogenicity because of a basic paucity of tumor-specific antigenicity. The ... -
The role of mutation in the new cancer paradigm
Prehn, Richmond T. (2005)The almost universal belief that cancer is caused by mutation may gradually be giving way to the belief that cancer begins as a cellular adaptation that involves the local epigenetic silencing of various genes. In my own ...